Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 7561..9120 Replicon plasmid unnamed1
Accession NZ_CP099736
Organism Photobacterium sp. TY1-4

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NH461_RS25390 Protein ID WP_261604673.1
Coordinates 7813..9120 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NH461_RS25385 Protein ID WP_261604672.1
Coordinates 7561..7812 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH461_RS25370 (NH461_25295) 2978..3946 + 969 WP_261604669.1 ParB family protein -
NH461_RS25375 (NH461_25300) 4013..5233 - 1221 WP_261604670.1 PD-(D/E)XK nuclease family protein -
NH461_RS25380 (NH461_25305) 5779..7425 + 1647 WP_261604671.1 hypothetical protein -
NH461_RS25385 (NH461_25310) 7561..7812 + 252 WP_261604672.1 helix-turn-helix domain-containing protein Antitoxin
NH461_RS25390 (NH461_25315) 7813..9120 + 1308 WP_261604673.1 type II toxin-antitoxin system HipA family toxin Toxin
NH461_RS25395 (NH461_25320) 9287..10249 - 963 WP_261604674.1 reverse transcriptase family protein -
NH461_RS25400 (NH461_25325) 10407..11144 - 738 WP_261604675.1 hypothetical protein -
NH461_RS25405 (NH461_25330) 11137..11637 - 501 WP_261604676.1 hypothetical protein -
NH461_RS25410 (NH461_25335) 12121..12942 - 822 WP_261604677.1 DUF2182 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..61276 61276


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-403)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-55)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 47782.13 Da        Isoelectric Point: 7.8526

>T249356 WP_261604673.1 NZ_CP099736:7813-9120 [Photobacterium sp. TY1-4]
MADLTIAMNGYPIGTLHRSPSGAHEFGYDESWLNTPGARPISLSLPLGRRRFKGEVVYNFFDNLLPDNMQIRQRIVARHH
AASSQPFDLLAEIGMDCVGALQIYPSRRQPEAVRTIHCKALDDTALRNILLGYRVDAPLGMISSEADFRISIAGAQEKTA
LLRQNGQWYLPLGSTPTTHILKLPIGAIQSPSHTIDLSASVENELVCLRLAAALGLPVAEAEMLTVGDIRALSVTRFDRR
LASDGQWIMRLPQEDFCQVLGVSPGLKYESDGGPGIVEIMTYLLGSVHPELDRATFMRAQVVFWLLAATDGHAKNFSVYL
LPDGAFRLTPLYDILSVYPVMGGAGLSERKVKMAMGLHGSKGRHYKWYSIFPRHFLATARAAGFDETAMQAILDEVRDKV
PAAVASVRASLPADFPAKISEAIFAGLLKRAQRMD

Download         Length: 1308 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9397.70 Da        Isoelectric Point: 8.0529

>AT249356 WP_261604672.1 NZ_CP099736:7561-7812 [Photobacterium sp. TY1-4]
MKVTSAHQLSHLLQDQRKQQGQSQCVIARKVGLRQDTVSKFENAPDGTRLDTLFKLLAALDLELEIRPRGEAAPAATQWK
EEW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References