Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 5393104..5393987 Replicon chromosome
Accession NZ_CP099727
Organism Pseudomonas putida strain PCL1760

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag NH673_RS24315 Protein ID WP_230064417.1
Coordinates 5393104..5393490 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A524BX56
Locus tag NH673_RS24320 Protein ID WP_014591577.1
Coordinates 5393538..5393987 (-) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH673_RS24295 (NH673_24295) 5388242..5389306 + 1065 WP_014591573.1 TerC family protein -
NH673_RS24300 (NH673_24300) 5389402..5390631 - 1230 WP_003250533.1 acyl-CoA dehydrogenase -
NH673_RS24305 (NH673_24305) 5390772..5391698 + 927 WP_014591574.1 LysR family transcriptional regulator -
NH673_RS24310 (NH673_24310) 5391892..5393046 + 1155 Protein_4791 aminotransferase class V-fold PLP-dependent enzyme -
NH673_RS24315 (NH673_24315) 5393104..5393490 - 387 WP_230064417.1 RES family NAD+ phosphorylase Toxin
NH673_RS24320 (NH673_24320) 5393538..5393987 - 450 WP_014591577.1 DUF2384 domain-containing protein Antitoxin
NH673_RS24325 (NH673_24325) 5394129..5394782 - 654 WP_014591578.1 oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB -
NH673_RS24330 (NH673_24330) 5394886..5395809 + 924 WP_019438774.1 LysR family transcriptional regulator -
NH673_RS24335 (NH673_24335) 5395858..5396688 + 831 WP_003250518.1 AraC family transcriptional regulator -
NH673_RS24340 (NH673_24340) 5396739..5397323 + 585 WP_014591580.1 LysE family transporter -
NH673_RS24345 (NH673_24345) 5397363..5398562 - 1200 WP_014591581.1 sugar transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-121)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(97-146)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14201.23 Da        Isoelectric Point: 5.5882

>T249350 WP_230064417.1 NZ_CP099727:c5393490-5393104 [Pseudomonas putida]
MRVSGRWHQAGRPVVYAATSPPGAMLEVLVHLEIDPEDFPTTMRLLRIELPDTVSQAQLPALQPGWSAQPELTRTLGNRF
LDDGSALLLPVPSAIMPSTTNYLFNPRHPQAQSAKIQVEDFTPDSRLF

Download         Length: 387 bp

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16984.51 Da        Isoelectric Point: 5.7258

>AT249350 WP_014591577.1 NZ_CP099727:c5393987-5393538 [Pseudomonas putida]
MLAEVLRDNGYHEYRARLQALLDIPELASDFEIHTRITDGFAATWLVKLTERGVLTPVERDQIIPLRTLKSRIERDQPLT
VDESDRLFRSAHITAMAEAVFGEVGKAKRWLSKPKERFSGLTPMQMLTTQQGTTQVEEMLLQIAEGYGL

Download         Length: 450 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A524BX56

References