Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 892638..893295 Replicon chromosome
Accession NC_014618
Organism Enterobacter lignolyticus SCF1

Toxin (Protein)


Gene name cptA Uniprot ID E3G4Y2
Locus tag ENTCL_RS04285 Protein ID WP_013364883.1
Coordinates 892885..893295 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID E3G4Y1
Locus tag ENTCL_RS04280 Protein ID WP_013364882.1
Coordinates 892638..892904 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ENTCL_RS04255 887897..889330 - 1434 WP_013364877.1 6-phospho-beta-glucosidase -
ENTCL_RS04260 889448..890179 - 732 WP_044612061.1 MurR/RpiR family transcriptional regulator -
ENTCL_RS04265 890231..890542 + 312 WP_013364879.1 N(4)-acetylcytidine aminohydrolase -
ENTCL_RS04270 890706..891365 + 660 WP_013364880.1 hemolysin III family protein -
ENTCL_RS04275 891407..892390 - 984 WP_013364881.1 tRNA-modifying protein YgfZ -
ENTCL_RS04280 892638..892904 + 267 WP_013364882.1 FAD assembly factor SdhE Antitoxin
ENTCL_RS04285 892885..893295 + 411 WP_013364883.1 protein YgfX Toxin
ENTCL_RS04290 893303..893824 - 522 WP_013364884.1 flavodoxin FldB -
ENTCL_RS04295 893924..894820 + 897 WP_013364885.1 site-specific tyrosine recombinase XerD -
ENTCL_RS04300 894843..895556 + 714 WP_013364886.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ENTCL_RS04305 895562..897295 + 1734 WP_013364887.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16081.99 Da        Isoelectric Point: 11.5522

>T24935 WP_013364883.1 NC_014618:892885-893295 [[Enterobacter] lignolyticus SCF1]
VVLWQSDLRVSWRAQWVSLLLHGLVAAAILLMPWPLSYTPLWLVLLSLVVFDCVRSQRRINARQGEIKLLMDSRLRWHNQ
EWEILGTPWIIKSGMMLRLRRIGSYKRIHLWIAADSMDAGEWRDLRRTISQQPAQQ

Download         Length: 411 bp

>T24935 NC_014618:892885-893295 [[Enterobacter] lignolyticus SCF1]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCGCTCAGTGGGTGTCTCTGCTGCTCCACGGCCTGGTGGCGGC
GGCGATATTGCTGATGCCCTGGCCGCTGAGCTACACCCCGCTCTGGCTGGTGCTCCTGTCGCTGGTGGTGTTCGACTGCG
TTCGCAGCCAGCGCCGCATCAACGCCCGTCAGGGGGAAATCAAGCTGCTGATGGATTCCCGCCTGCGCTGGCATAACCAG
GAGTGGGAAATTCTTGGCACCCCCTGGATCATCAAAAGTGGGATGATGCTGCGCTTACGCAGAATCGGAAGCTACAAGAG
AATACACCTGTGGATTGCGGCTGACAGCATGGATGCCGGAGAGTGGCGGGATTTGCGCCGGACAATATCGCAGCAGCCGG
CGCAGCAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10500.04 Da        Isoelectric Point: 5.1114

>AT24935 WP_013364882.1 NC_014618:892638-892904 [[Enterobacter] lignolyticus SCF1]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDSDKQLFIRLLECDDPDLFNWLMNHGKPADAELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT24935 NC_014618:892638-892904 [[Enterobacter] lignolyticus SCF1]
ATGGACATTACTAATAAAGCCCGTATCCATTGGGCATGCCGCCGCGGTATGCGTGAGCTCGATATTTCCATCATGCCGTT
CTTTGAATATGAATACGACACGTTGAGCGACAGCGATAAGCAGCTCTTTATTCGCCTTCTGGAGTGCGACGACCCCGATC
TTTTCAACTGGCTGATGAACCACGGGAAGCCAGCGGACGCGGAACTGCAAAGGATGGTGCAACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3G4Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A806XG21

References