249340

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 124844..125469 Replicon plasmid pGDE043-2
Accession NZ_CP099723
Organism Escherichia coli strain EC21GDE043

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NH569_RS26185 Protein ID WP_000911333.1
Coordinates 125071..125469 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag NH569_RS26180 Protein ID WP_000450520.1
Coordinates 124844..125071 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH569_RS26180 (124844) 124844..125071 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
NH569_RS26185 (125071) 125071..125469 + 399 WP_000911333.1 tRNA(fMet)-specific endonuclease VapC Toxin
NH569_RS26190 (125478) 125478..127631 - 2154 WP_000009379.1 type IV conjugative transfer system coupling protein TraD -
NH569_RS26195 (127884) 127884..128594 - 711 WP_231793510.1 conjugal transfer complement resistance protein TraT -
NH569_RS26200 (128629) 128629..129138 - 510 WP_000628105.1 conjugal transfer entry exclusion protein TraS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid qnrS1 / blaLAP-2 / dfrA14 / ant(3'')-Ia / blaOXA-10 / cmlA1 / ARR-3 / sitABCD iroB / iroC / iroD / iroE / iroN / vat / iutA / iucD / iucC / iucB / iucA 1..203860 203860


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14919.19 Da        Isoelectric Point: 7.8605

>T249340 WP_000911333.1 NZ_CP099723:125071-125469 [Escherichia coli]
MLKFMLDTNICIFTMKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT249340 WP_000450520.1 NZ_CP099723:124844-125071 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References