249335

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 4160651..4161465 Replicon chromosome
Accession NZ_CP099721
Organism Escherichia coli strain EC21GDE043

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag NH569_RS20420 Protein ID WP_001054376.1
Coordinates 4160651..4160908 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID A0A8E0IVE5
Locus tag NH569_RS20425 Protein ID WP_001350781.1
Coordinates 4160920..4161465 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH569_RS20395 (4155939) 4155939..4157045 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
NH569_RS20400 (4157110) 4157110..4158090 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
NH569_RS20405 (4158200) 4158200..4158405 + 206 Protein_3993 HNH endonuclease -
NH569_RS20410 (4158673) 4158673..4159913 - 1241 Protein_3994 helicase YjhR -
NH569_RS20415 (4160029) 4160029..4160160 + 132 WP_001309182.1 hypothetical protein -
NH569_RS20420 (4160651) 4160651..4160908 + 258 WP_001054376.1 YjhX family toxin Toxin
NH569_RS20425 (4160920) 4160920..4161465 + 546 WP_001350781.1 N-acetyltransferase Antitoxin
NH569_RS20430 (4161521) 4161521..4162267 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
NH569_RS20435 (4162436) 4162436..4162654 + 219 Protein_3999 hypothetical protein -
NH569_RS20440 (4162692) 4162692..4162808 + 117 Protein_4000 VOC family protein -
NH569_RS20445 (4163053) 4163053..4163904 + 852 Protein_4001 M42 family peptidase -
NH569_RS20450 (4163960) 4163960..4165173 + 1214 WP_139371347.1 IS3 family transposase -
NH569_RS20455 (4165511) 4165511..4165792 - 282 WP_223349491.1 biofilm development regulator YmgB/AriR family protein -
NH569_RS20460 (4166107) 4166107..4166211 - 105 Protein_4004 IS3 family transposase -
NH569_RS20465 (4166256) 4166256..4166387 - 132 Protein_4005 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 4150437..4166738 16301


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T249335 WP_001054376.1 NZ_CP099721:4160651-4160908 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19974.91 Da        Isoelectric Point: 6.3277

>AT249335 WP_001350781.1 NZ_CP099721:4160920-4161465 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAFIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure

References