Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3521696..3522314 Replicon chromosome
Accession NZ_CP099721
Organism Escherichia coli strain EC21GDE043

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NH569_RS17240 Protein ID WP_001291435.1
Coordinates 3522096..3522314 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NH569_RS17235 Protein ID WP_000344800.1
Coordinates 3521696..3522070 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH569_RS17225 (3516786) 3516786..3517979 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NH569_RS17230 (3518002) 3518002..3521151 + 3150 WP_001132463.1 efflux RND transporter permease AcrB -
NH569_RS17235 (3521696) 3521696..3522070 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NH569_RS17240 (3522096) 3522096..3522314 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NH569_RS17245 (3522488) 3522488..3523039 + 552 WP_000102543.1 maltose O-acetyltransferase -
NH569_RS17250 (3523155) 3523155..3523625 + 471 WP_000136192.1 YlaC family protein -
NH569_RS17255 (3523789) 3523789..3525339 + 1551 WP_001350616.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NH569_RS17260 (3525381) 3525381..3525734 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NH569_RS17270 (3526113) 3526113..3526424 + 312 WP_000409908.1 MGMT family protein -
NH569_RS17275 (3526455) 3526455..3527027 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T249328 WP_001291435.1 NZ_CP099721:3522096-3522314 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT249328 WP_000344800.1 NZ_CP099721:3521696-3522070 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References