Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2461047..2462635 Replicon chromosome
Accession NZ_CP099721
Organism Escherichia coli strain EC21GDE043

Toxin (Protein)


Gene name hipA Uniprot ID B7MMY1
Locus tag NH569_RS12005 Protein ID WP_001125475.1
Coordinates 2461313..2462635 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NH569_RS12000 Protein ID WP_001332145.1
Coordinates 2461047..2461313 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH569_RS11985 (2457415) 2457415..2458866 + 1452 WP_001513806.1 tagaturonate reductase -
NH569_RS11990 (2459063) 2459063..2459977 + 915 WP_001306069.1 bestrophin family protein -
NH569_RS11995 (2459981) 2459981..2460739 - 759 WP_001286588.1 trans-aconitate 2-methyltransferase -
NH569_RS12000 (2461047) 2461047..2461313 + 267 WP_001332145.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NH569_RS12005 (2461313) 2461313..2462635 + 1323 WP_001125475.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
NH569_RS12010 (2462945) 2462945..2463127 - 183 Protein_2350 hypothetical protein -
NH569_RS12015 (2463261) 2463261..2464043 + 783 WP_001221834.1 SDR family oxidoreductase -
NH569_RS12020 (2464287) 2464287..2464394 - 108 Protein_2352 hypothetical protein -
NH569_RS12025 (2464819) 2464819..2465382 + 564 WP_001296074.1 type 1 fimbrial major subunit FimA -
NH569_RS12030 (2465744) 2465744..2466454 + 711 WP_001195181.1 fimbria/pilus periplasmic chaperone -
NH569_RS12035 (2466496) 2466496..2466966 + 471 Protein_2355 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49426.24 Da        Isoelectric Point: 8.9380

>T249325 WP_001125475.1 NZ_CP099721:2461313-2462635 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.44 Da        Isoelectric Point: 6.2267

>AT249325 WP_001332145.1 NZ_CP099721:2461047-2461313 [Escherichia coli]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L5M8

Antitoxin

Source ID Structure

References