Detailed information of TA system TA024932

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2287591..2288063
• Replicon: chromosome
• Accession: NC_014614
• Organism: Clostridium sticklandii

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CLOST_RS10865
• Protein ID: WP_013362371.1
• Coordinates: 2287591..2287854 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CLOST_RS10870
• Protein ID: WP_013362372.1
• Coordinates: 2287851..2288063 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CLOST_RS10830	2282773..2283354	-	582	WP_013362364.1	DUF3841 domain-containing protein	-
CLOST_RS10835	2283377..2284114	-	738	WP_013362365.1	nitroreductase	-
CLOST_RS10840	2284150..2284926	-	777	WP_041487203.1	hypothetical protein	-
CLOST_RS13635	2284904..2285497	-	594	WP_013362367.1	hypothetical protein	-
CLOST_RS10850	2285636..2285839	-	204	WP_013362368.1	PTS ascorbate transporter subunit IIC	-
CLOST_RS10855	2285867..2286874	-	1008	WP_013362369.1	SPFH domain-containing protein	-
CLOST_RS10860	2287115..2287534	-	420	WP_013362370.1	DUF523 domain-containing protein	-
CLOST_RS10865	2287591..2287854	-	264	WP_013362371.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CLOST_RS10870	2287851..2288063	-	213	WP_013362372.1	ribbon-helix-helix protein, CopG family	Antitoxin
CLOST_RS10875	2288211..2288603	-	393	WP_013362373.1	30S ribosomal protein S9	-
CLOST_RS10880	2288628..2289056	-	429	WP_013362374.1	50S ribosomal protein L13	-
CLOST_RS10885	2289157..2289906	-	750	WP_013362375.1	tRNA pseudouridine(38-40) synthase TruA	-
CLOST_RS10890	2289906..2290709	-	804	WP_013362376.1	energy-coupling factor transporter transmembrane protein EcfT	-
CLOST_RS10895	2290702..2291565	-	864	WP_013362378.1	energy-coupling factor transporter ATPase	-
CLOST_RS10900	2291556..2292386	-	831	WP_013362379.1	energy-coupling factor transporter ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• Protein of unknown function DUF6290 (2-68)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10345.14 Da
• Isoelectric Point: 9.8067

>T24932 WP_013362371.1 NC_014614:c2287854-2287591 [[Clostridium] sticklandii]
MSYKLIYSEDSLKQLKKLDKSVQKLIVRYLRNLETLEEPRAKGKALSANLKGFWRYRIADYRVICEIDDDKIIIIVIDIG
HRKNIYD

Nucleotide

• Length: 264 bp

>T24932 NC_014614:c2287854-2287591 [[Clostridium] sticklandii]
ATGAGTTATAAATTAATTTATTCAGAAGATAGCTTAAAGCAGTTAAAAAAATTAGATAAGTCTGTTCAAAAACTAATTGT
ACGATATCTTAGAAATCTTGAAACTTTAGAAGAACCTAGAGCAAAAGGAAAGGCTCTGTCTGCTAATTTAAAAGGATTTT
GGAGATATCGTATTGCAGATTATAGAGTAATATGTGAAATTGATGATGACAAGATAATTATTATAGTAATAGATATAGGG
CACAGAAAAAATATTTATGACTAG

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 8213.43 Da
• Isoelectric Point: 4.6820

>AT24932 WP_013362372.1 NC_014614:c2288063-2287851 [[Clostridium] sticklandii]
MLSIRCSSEDENLIKKYAAMKKQSVSEFLRQAALEKIEDEYDLKLVKDYLDKKEKMSFYSADEVEKELGI

Nucleotide

• Length: 213 bp

>AT24932 NC_014614:c2288063-2287851 [[Clostridium] sticklandii]
ATGCTTTCAATAAGATGTAGTTCAGAAGATGAGAATTTAATAAAAAAATATGCAGCCATGAAAAAGCAAAGTGTATCAGA
GTTTTTGAGACAAGCAGCACTAGAAAAAATAGAAGATGAATATGATTTAAAGCTAGTAAAGGACTATTTGGATAAAAAAG
AAAAAATGAGTTTTTATTCTGCTGATGAAGTAGAAAAGGAACTTGGTATATGA