Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2287591..2288063 Replicon chromosome
Accession NC_014614
Organism Clostridium sticklandii

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CLOST_RS10865 Protein ID WP_013362371.1
Coordinates 2287591..2287854 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CLOST_RS10870 Protein ID WP_013362372.1
Coordinates 2287851..2288063 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLOST_RS10830 2282773..2283354 - 582 WP_013362364.1 DUF3841 domain-containing protein -
CLOST_RS10835 2283377..2284114 - 738 WP_013362365.1 nitroreductase -
CLOST_RS10840 2284150..2284926 - 777 WP_041487203.1 hypothetical protein -
CLOST_RS13635 2284904..2285497 - 594 WP_013362367.1 hypothetical protein -
CLOST_RS10850 2285636..2285839 - 204 WP_013362368.1 PTS ascorbate transporter subunit IIC -
CLOST_RS10855 2285867..2286874 - 1008 WP_013362369.1 SPFH domain-containing protein -
CLOST_RS10860 2287115..2287534 - 420 WP_013362370.1 DUF523 domain-containing protein -
CLOST_RS10865 2287591..2287854 - 264 WP_013362371.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CLOST_RS10870 2287851..2288063 - 213 WP_013362372.1 ribbon-helix-helix protein, CopG family Antitoxin
CLOST_RS10875 2288211..2288603 - 393 WP_013362373.1 30S ribosomal protein S9 -
CLOST_RS10880 2288628..2289056 - 429 WP_013362374.1 50S ribosomal protein L13 -
CLOST_RS10885 2289157..2289906 - 750 WP_013362375.1 tRNA pseudouridine(38-40) synthase TruA -
CLOST_RS10890 2289906..2290709 - 804 WP_013362376.1 energy-coupling factor transporter transmembrane protein EcfT -
CLOST_RS10895 2290702..2291565 - 864 WP_013362378.1 energy-coupling factor transporter ATPase -
CLOST_RS10900 2291556..2292386 - 831 WP_013362379.1 energy-coupling factor transporter ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

Protein of unknown function DUF6290

(2-68)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10345.14 Da        Isoelectric Point: 9.8067

>T24932 WP_013362371.1 NC_014614:c2287854-2287591 [[Clostridium] sticklandii]
MSYKLIYSEDSLKQLKKLDKSVQKLIVRYLRNLETLEEPRAKGKALSANLKGFWRYRIADYRVICEIDDDKIIIIVIDIG
HRKNIYD

Download         Length: 264 bp

>T24932 NC_014614:c2287854-2287591 [[Clostridium] sticklandii]
ATGAGTTATAAATTAATTTATTCAGAAGATAGCTTAAAGCAGTTAAAAAAATTAGATAAGTCTGTTCAAAAACTAATTGT
ACGATATCTTAGAAATCTTGAAACTTTAGAAGAACCTAGAGCAAAAGGAAAGGCTCTGTCTGCTAATTTAAAAGGATTTT
GGAGATATCGTATTGCAGATTATAGAGTAATATGTGAAATTGATGATGACAAGATAATTATTATAGTAATAGATATAGGG
CACAGAAAAAATATTTATGACTAG

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 8213.43 Da        Isoelectric Point: 4.6820

>AT24932 WP_013362372.1 NC_014614:c2288063-2287851 [[Clostridium] sticklandii]
MLSIRCSSEDENLIKKYAAMKKQSVSEFLRQAALEKIEDEYDLKLVKDYLDKKEKMSFYSADEVEKELGI

Download         Length: 213 bp

>AT24932 NC_014614:c2288063-2287851 [[Clostridium] sticklandii]
ATGCTTTCAATAAGATGTAGTTCAGAAGATGAGAATTTAATAAAAAAATATGCAGCCATGAAAAAGCAAAGTGTATCAGA
GTTTTTGAGACAAGCAGCACTAGAAAAAATAGAAGATGAATATGATTTAAAGCTAGTAAAGGACTATTTGGATAAAAAAG
AAAAAATGAGTTTTTATTCTGCTGATGAAGTAGAAAAGGAACTTGGTATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References