Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 996042..996696 Replicon chromosome
Accession NZ_CP099721
Organism Escherichia coli strain EC21GDE043

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag NH569_RS04925 Protein ID WP_000244781.1
Coordinates 996289..996696 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NH569_RS04920 Protein ID WP_000354046.1
Coordinates 996042..996308 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH569_RS04900 (992130) 992130..993563 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
NH569_RS04905 (993608) 993608..993919 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
NH569_RS04910 (994083) 994083..994742 + 660 WP_000250274.1 hemolysin III family protein -
NH569_RS04915 (994819) 994819..995799 - 981 WP_000886078.1 tRNA-modifying protein YgfZ -
NH569_RS04920 (996042) 996042..996308 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NH569_RS04925 (996289) 996289..996696 + 408 WP_000244781.1 protein YgfX Toxin
NH569_RS04930 (996736) 996736..997257 - 522 WP_001055874.1 flavodoxin FldB -
NH569_RS04935 (997369) 997369..998265 + 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
NH569_RS04940 (998290) 998290..999000 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NH569_RS04945 (999006) 999006..1000739 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T249317 WP_000244781.1 NZ_CP099721:996289-996696 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT249317 WP_000354046.1 NZ_CP099721:996042-996308 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References