Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 707362..708194 Replicon chromosome
Accession NZ_CP099721
Organism Escherichia coli strain EC21GDE043

Toxin (Protein)


Gene name yeeV Uniprot ID F4TJC5
Locus tag NH569_RS03460 Protein ID WP_001094452.1
Coordinates 707820..708194 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID F4TJC4
Locus tag NH569_RS03455 Protein ID WP_001285579.1
Coordinates 707362..707730 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH569_RS03435 (705111) 705111..705929 + 819 WP_001564116.1 DUF932 domain-containing protein -
NH569_RS03440 (706021) 706021..706506 + 486 WP_000206669.1 antirestriction protein -
NH569_RS03445 (706522) 706522..706998 + 477 WP_001186706.1 RadC family protein -
NH569_RS03450 (707061) 707061..707282 + 222 WP_000692345.1 DUF987 domain-containing protein -
NH569_RS03455 (707362) 707362..707730 + 369 WP_001285579.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NH569_RS03460 (707820) 707820..708194 + 375 WP_001094452.1 TA system toxin CbtA family protein Toxin
NH569_RS03465 (708191) 708191..708682 + 492 WP_000976868.1 DUF5983 family protein -
NH569_RS03470 (708694) 708694..708891 + 198 WP_000772035.1 DUF957 domain-containing protein -
NH569_RS03475 (708988) 708988..709833 + 846 WP_021539310.1 DUF4942 domain-containing protein -
NH569_RS03485 (710133) 710133..710639 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
NH569_RS03490 (710718) 710718..712559 - 1842 WP_000437380.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14014.86 Da        Isoelectric Point: 7.2920

>T249315 WP_001094452.1 NZ_CP099721:707820-708194 [Escherichia coli]
MNTLPDTHVREASRCSSPVTIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSTDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13580.39 Da        Isoelectric Point: 7.3223

>AT249315 WP_001285579.1 NZ_CP099721:707362-707730 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSCGYVYLAVYPTSETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7YIM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8DWX2

References