Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4427584..4429157 Replicon chromosome
Accession NZ_CP099717
Organism Aeromonas encheleia strain SOD01

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NHF51_RS20340 Protein ID WP_252995312.1
Coordinates 4427584..4428903 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A3Q8DTG9
Locus tag NHF51_RS20345 Protein ID WP_042047685.1
Coordinates 4428903..4429157 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF51_RS20325 (NHF51_20325) 4423474..4424238 + 765 WP_252995309.1 ATP-binding cassette domain-containing protein -
NHF51_RS20330 (NHF51_20330) 4424251..4425180 + 930 WP_252995310.1 ABC transporter substrate-binding protein -
NHF51_RS20335 (NHF51_20335) 4425177..4427159 + 1983 WP_252995311.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -
NHF51_RS20340 (NHF51_20340) 4427584..4428903 - 1320 WP_252995312.1 type II toxin-antitoxin system HipA family toxin Toxin
NHF51_RS20345 (NHF51_20345) 4428903..4429157 - 255 WP_042047685.1 helix-turn-helix domain-containing protein Antitoxin
NHF51_RS20350 (NHF51_20350) 4429696..4430319 + 624 WP_252995313.1 recombinase family protein -
NHF51_RS20355 (NHF51_20355) 4431107..4433572 + 2466 WP_252995314.1 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49426.39 Da        Isoelectric Point: 6.8288

>T249311 WP_252995312.1 NZ_CP099717:c4428903-4427584 [Aeromonas encheleia]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFDRSAMEEILTELANSV
DDVIERVTQQLPAGFPDTISSAILEGLKARSARLIKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9293.62 Da        Isoelectric Point: 7.9834

>AT249311 WP_042047685.1 NZ_CP099717:c4429157-4428903 [Aeromonas encheleia]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIKPRNESSDSPASGW
KEEW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q8DTG9

References