Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-YefM
Location 19982..20498 Replicon plasmid pDK313-83
Accession NZ_CP099715
Organism Dietzia kunjamensis strain 313

Toxin (Protein)


Gene name relB Uniprot ID A0A166Q8Z2
Locus tag NHB83_RS18290 Protein ID WP_061228632.1
Coordinates 19982..20239 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A022L238
Locus tag NHB83_RS18295 Protein ID WP_017836490.1
Coordinates 20241..20498 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHB83_RS18270 (NHB83_18270) 16466..17299 - 834 WP_253003999.1 glycosyltransferase family 2 protein -
NHB83_RS18275 (NHB83_18275) 17574..18365 - 792 WP_276534175.1 polysaccharide deacetylase family protein -
NHB83_RS18280 (NHB83_18280) 18739..19014 - 276 WP_253004001.1 WhiB family transcriptional regulator -
NHB83_RS18285 (NHB83_18285) 19143..19871 + 729 WP_253004002.1 response regulator transcription factor -
NHB83_RS18290 (NHB83_18290) 19982..20239 - 258 WP_061228632.1 Txe/YoeB family addiction module toxin Toxin
NHB83_RS18295 (NHB83_18295) 20241..20498 - 258 WP_017836490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
NHB83_RS18300 (NHB83_18300) 20964..21533 + 570 WP_253004003.1 DNA-binding protein -
NHB83_RS18305 (NHB83_18305) 21678..22001 + 324 WP_253004004.1 hypothetical protein -
NHB83_RS18310 (NHB83_18310) 22084..22629 - 546 WP_253004005.1 hypothetical protein -
NHB83_RS18315 (NHB83_18315) 22652..23008 - 357 WP_253004006.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..83561 83561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10355.73 Da        Isoelectric Point: 8.0063

>T249310 WP_061228632.1 NZ_CP099715:c20239-19982 [Dietzia kunjamensis]
VLLVWDDNAWQDYLWWQQQDRKILKRINLLLQDITRNGNEGIGKPEPLKYDFAGYWSRRITDEHRLVYKVTDTEVRIATC
RYHYG

Download         Length: 258 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9652.81 Da        Isoelectric Point: 4.6899

>AT249310 WP_017836490.1 NZ_CP099715:c20498-20241 [Dietzia kunjamensis]
MKTMSYTESRARYAEVLDGVTNDREEVIITRAGHEPVVMVSLDDYESLRETAHLMRSPANARRLLDAMERLESGRGQARD
LLDAD

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A166Q8Z2

Antitoxin

Source ID Structure
AlphaFold DB A0A022L238

References