Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-YefM
Location 7521..8037 Replicon plasmid pDK313-83
Accession NZ_CP099715
Organism Dietzia kunjamensis strain 313

Toxin (Protein)


Gene name relB Uniprot ID A0A166Q8Z2
Locus tag NHB83_RS18235 Protein ID WP_061228632.1
Coordinates 7521..7778 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag NHB83_RS18240 Protein ID WP_213186331.1
Coordinates 7780..8037 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHB83_RS18195 (NHB83_18195) 3498..4028 + 531 WP_253003990.1 Asp23/Gls24 family envelope stress response protein -
NHB83_RS18200 (NHB83_18200) 4109..4285 + 177 WP_181366004.1 hypothetical protein -
NHB83_RS18205 (NHB83_18205) 4343..4738 + 396 WP_253004019.1 Asp23/Gls24 family envelope stress response protein -
NHB83_RS18210 (NHB83_18210) 4735..5289 + 555 WP_109149176.1 DUF6286 domain-containing protein -
NHB83_RS18215 (NHB83_18215) 5303..5950 + 648 WP_253003991.1 hypothetical protein -
NHB83_RS18220 (NHB83_18220) 5947..6525 + 579 WP_253003992.1 RNA polymerase sigma factor -
NHB83_RS18225 (NHB83_18225) 6516..7040 + 525 WP_253003993.1 hypothetical protein -
NHB83_RS18230 (NHB83_18230) 7030..7350 + 321 WP_204650741.1 hypothetical protein -
NHB83_RS18235 (NHB83_18235) 7521..7778 - 258 WP_061228632.1 Txe/YoeB family addiction module toxin Toxin
NHB83_RS18240 (NHB83_18240) 7780..8037 - 258 WP_213186331.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
NHB83_RS18245 (NHB83_18245) 8501..9079 + 579 WP_253003994.1 DNA-binding protein -
NHB83_RS18250 (NHB83_18250) 9260..10483 - 1224 WP_253003995.1 cellulase family glycosylhydrolase -
NHB83_RS18255 (NHB83_18255) 10625..12715 - 2091 WP_253003996.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..83561 83561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10355.73 Da        Isoelectric Point: 8.0063

>T249309 WP_061228632.1 NZ_CP099715:c7778-7521 [Dietzia kunjamensis]
VLLVWDDNAWQDYLWWQQQDRKILKRINLLLQDITRNGNEGIGKPEPLKYDFAGYWSRRITDEHRLVYKVTDTEVRIATC
RYHYG

Download         Length: 258 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9666.83 Da        Isoelectric Point: 4.7010

>AT249309 WP_213186331.1 NZ_CP099715:c8037-7780 [Dietzia kunjamensis]
MKTMSYTESRARYAEVLDGVTNDREEVIITRAGHEPVVMVSLDEYESLRETAHLMRSPANARRLLDAMERLESGRGQARD
LLDAD

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A166Q8Z2

Antitoxin

Source ID Structure

References