Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4323173..4323954 | Replicon | chromosome |
| Accession | NZ_CP099705 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain 013+ | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | NG892_RS21140 | Protein ID | WP_000626099.1 |
| Coordinates | 4323173..4323664 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | NG892_RS21145 | Protein ID | WP_001110452.1 |
| Coordinates | 4323661..4323954 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NG892_RS21105 (4319168) | 4319168..4319743 | + | 576 | WP_001188509.1 | transcriptional regulator | - |
| NG892_RS21115 (4320014) | 4320014..4320091 | - | 78 | Protein_4125 | helix-turn-helix domain-containing protein | - |
| NG892_RS21120 (4320182) | 4320182..4320514 | - | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| NG892_RS21125 (4320586) | 4320586..4320963 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| NG892_RS21130 (4321996) | 4321996..4322070 | + | 75 | Protein_4128 | porin family protein | - |
| NG892_RS21135 (4322173) | 4322173..4322925 | + | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| NG892_RS21140 (4323173) | 4323173..4323664 | - | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| NG892_RS21145 (4323661) | 4323661..4323954 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| NG892_RS21150 (4324271) | 4324271..4324492 | + | 222 | WP_001576552.1 | hypothetical protein | - |
| NG892_RS21155 (4324757) | 4324757..4325632 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| NG892_RS21160 (4325629) | 4325629..4325916 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| NG892_RS21165 (4325939) | 4325939..4326154 | + | 216 | WP_001595136.1 | hypothetical protein | - |
| NG892_RS21170 (4326162) | 4326162..4326431 | + | 270 | WP_010989096.1 | hypothetical protein | - |
| NG892_RS21175 (4326725) | 4326725..4327630 | - | 906 | Protein_4137 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T249304 WP_000626099.1 NZ_CP099705:c4323664-4323173 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT249304 WP_001110452.1 NZ_CP099705:c4323954-4323661 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 | |
| AlphaFold DB | A0A5I1DGA4 |