Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpA-AbkA/BrnT_toxin-BrnA
Location 4543262..4543867 Replicon chromosome
Accession NZ_CP099647
Organism Paraburkholderia fungorum strain OTU2SAUBB1

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag NHH62_RS39695 Protein ID WP_081923075.1
Coordinates 4543562..4543867 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name AbkA Uniprot ID A0A2T1ARB7
Locus tag NHH62_RS39690 Protein ID WP_030102352.1
Coordinates 4543262..4543519 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHH62_RS39670 (NHH62_39670) 4538518..4539270 + 753 WP_030102350.1 5-oxoprolinase subunit PxpA -
NHH62_RS39675 (NHH62_39675) 4539544..4540293 + 750 WP_028198554.1 DUF969 domain-containing protein -
NHH62_RS39680 (NHH62_39680) 4540290..4541246 + 957 WP_028198553.1 DUF979 domain-containing protein -
NHH62_RS39685 (NHH62_39685) 4541460..4543265 + 1806 WP_030102351.1 tetratricopeptide repeat protein -
NHH62_RS39690 (NHH62_39690) 4543262..4543519 - 258 WP_030102352.1 BrnA antitoxin family protein Antitoxin
NHH62_RS39695 (NHH62_39695) 4543562..4543867 - 306 WP_081923075.1 BrnT family toxin Toxin
NHH62_RS39700 (NHH62_39700) 4544048..4545199 - 1152 WP_030102354.1 TraB/GumN family protein -
NHH62_RS39705 (NHH62_39705) 4545192..4546211 - 1020 WP_028198550.1 peptide ABC transporter ATP-binding protein -
NHH62_RS39710 (NHH62_39710) 4546208..4547212 - 1005 WP_030102356.1 ABC transporter ATP-binding protein -
NHH62_RS39715 (NHH62_39715) 4547214..4548131 - 918 WP_028198548.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(14-91)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-77)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12095.90 Da        Isoelectric Point: 10.2615

>T249285 WP_081923075.1 NZ_CP099647:c4543867-4543562 [Paraburkholderia fungorum]
MYKRKYGWRVRFEWDEVKNQINIRTHGIDFRDAVNVFDHPVLTAMDQRQDYGEDRWIALGWMVAIVGVVVYVERSADVVR
IISARKATKHEVKRFKQSVWN

Download         Length: 306 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9793.09 Da        Isoelectric Point: 9.6912

>AT249285 WP_030102352.1 NZ_CP099647:c4543519-4543262 [Paraburkholderia fungorum]
MGKTSGTDWKRLAKTNDAQIDTSDVPELGDDFFDRAELHVPPKQAVTMRLDADVLNWFKEQGAGYQTRINKLLRAYMLAQ
QRRRP

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2T1ARB7

References