Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2159223..2159825 Replicon chromosome
Accession NZ_CP099645
Organism Paraburkholderia fungorum strain OTU2SAUBB1

Toxin (Protein)


Gene name PumA Uniprot ID A0A2N8Q3W2
Locus tag NHH62_RS11865 Protein ID WP_028194450.1
Coordinates 2159223..2159522 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A0D5VNN5
Locus tag NHH62_RS11870 Protein ID WP_028194449.1
Coordinates 2159526..2159825 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHH62_RS11850 (NHH62_11855) 2155514..2156467 - 954 WP_235430069.1 choline ABC transporter substrate-binding protein -
NHH62_RS11855 (NHH62_11860) 2156530..2158077 - 1548 WP_030100588.1 choline-sulfatase -
NHH62_RS11860 (NHH62_11865) 2158230..2159144 + 915 WP_030100589.1 LysR family transcriptional regulator -
NHH62_RS11865 (NHH62_11870) 2159223..2159522 + 300 WP_028194450.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NHH62_RS11870 (NHH62_11875) 2159526..2159825 + 300 WP_028194449.1 putative addiction module antidote protein Antitoxin
NHH62_RS11875 (NHH62_11880) 2159997..2160872 + 876 WP_030100590.1 formyltetrahydrofolate deformylase -
NHH62_RS11880 (NHH62_11885) 2160967..2161824 - 858 WP_028194447.1 glycine betaine ABC transporter substrate-binding protein -
NHH62_RS11885 (NHH62_11890) 2161968..2163224 - 1257 WP_096335844.1 hybrid-cluster NAD(P)-dependent oxidoreductase -
NHH62_RS11890 (NHH62_11895) 2163261..2164571 - 1311 WP_030100592.1 aromatic ring-hydroxylating dioxygenase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2158272..2163224 4952


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-87)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-92)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11009.69 Da        Isoelectric Point: 9.6247

>T249281 WP_028194450.1 NZ_CP099645:2159223-2159522 [Paraburkholderia fungorum]
MLKIRTTETFDAWFDGLKDRIARRRIQARIDRLAMGNPGDTNSAGAPIIELRIDHGPGYRVYYVQRGAVLVILLCGGDKS
TQPADIKAAHKMLANLESE

Download         Length: 300 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10603.11 Da        Isoelectric Point: 6.0723

>AT249281 WP_028194449.1 NZ_CP099645:2159526-2159825 [Paraburkholderia fungorum]
MGKIKTRPWDSAEHLKTEADMAEYFEACLVEGGDDPAFLAHALGVIARARGMAQLARDTGISREGLYKALSEDGNPSFAT
IIKVIRALGLELHAAPAHA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N8Q3W2

Antitoxin

Source ID Structure
AlphaFold DB A0A0D5VNN5

References