249280

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 433559..435352 Replicon chromosome
Accession NZ_CP099645
Organism Paraburkholderia fungorum strain OTU2SAUBB1

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NHH62_RS04115 Protein ID WP_030103727.1
Coordinates 433559..434458 (+) Length 300 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag NHH62_RS04120 Protein ID WP_028195929.1
Coordinates 434459..435352 (+) Length 298 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHH62_RS04085 (NHH62_04085) 428909..429985 - 1077 WP_030103722.1 porin -
NHH62_RS04090 (NHH62_04090) 430427..430741 + 315 WP_028195935.1 non-heme iron oxygenase ferredoxin subunit -
NHH62_RS04095 (NHH62_04095) 430743..431054 + 312 WP_030103723.1 hypothetical protein -
NHH62_RS04100 (NHH62_04100) 431104..432201 + 1098 WP_030103724.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
NHH62_RS04105 (NHH62_04105) 432194..432970 + 777 WP_030103725.1 SDR family oxidoreductase -
NHH62_RS04110 (NHH62_04110) 432997..433524 + 528 WP_030103726.1 cupin domain-containing protein -
NHH62_RS04115 (NHH62_04115) 433559..434458 + 900 WP_030103727.1 alpha/beta hydrolase Toxin
NHH62_RS04120 (NHH62_04120) 434459..435352 + 894 WP_028195929.1 IclR family transcriptional regulator Antitoxin
NHH62_RS04125 (NHH62_04125) 435349..436158 + 810 WP_030103728.1 SDR family oxidoreductase -
NHH62_RS04130 (NHH62_04130) 436151..437809 + 1659 WP_030103729.1 thiamine pyrophosphate-binding protein -
NHH62_RS04135 (NHH62_04135) 437802..438632 + 831 WP_030103730.1 aspartate dehydrogenase -
NHH62_RS04140 (NHH62_04140) 438665..440155 + 1491 WP_030103731.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(53-282)

Antitoxin

Transcription regulator IclR, N-terminal

(32-80)


Sequences

Toxin        


Download         Length: 300 a.a.        Molecular weight: 31588.83 Da        Isoelectric Point: 6.4891

>T249280 WP_030103727.1 NZ_CP099645:433559-434458 [Paraburkholderia fungorum]
MSAVPSRIADNVDQNATLEARLARFPAQQIWLASQRAVSYREADSAASDALPLVLLHGIGSGAASWVQQFEMLGETRRVL
AWDAPGYGASTPVDAVSPVAGDYATVLKEWLDALGIERCVLLGHSLGAIVAGAFAVTNPQLVAGLLLLSPAGGYGASPAD
VRESKRNQRLAMIKELGPQGLAEKRSTNMLSANASDEARAWVRWNMSRVIPRGYVQATHLLANADLASDLARYKGRISIA
VGADDAITPPEACERLALTAGTRLQVVPGAGHAGYIEAPTAYTAIIDTFCRASDGQRSQ

Download         Length: 900 bp

>T249280 NZ_CP099645:433559-434458 [Paraburkholderia fungorum]
ATGTCCGCAGTCCCGTCCCGTATCGCCGATAACGTCGATCAGAACGCTACGCTCGAAGCGCGCCTTGCACGCTTTCCGGC
GCAGCAGATCTGGCTCGCATCGCAACGTGCGGTGAGTTATCGCGAGGCGGATAGCGCCGCAAGCGACGCACTGCCTTTGG
TGCTGCTTCACGGTATCGGGTCGGGCGCGGCTTCGTGGGTACAACAGTTTGAAATGCTGGGCGAGACGCGCCGTGTGCTG
GCGTGGGATGCGCCGGGATATGGCGCGTCGACCCCGGTAGACGCCGTTTCACCTGTCGCCGGCGACTACGCAACGGTGCT
GAAAGAATGGCTCGACGCGCTCGGCATCGAACGCTGTGTGTTGCTCGGGCATTCGCTTGGCGCGATCGTCGCCGGTGCGT
TTGCTGTGACGAATCCGCAGCTTGTGGCCGGTTTACTCCTGCTGTCGCCGGCTGGCGGATATGGCGCTTCGCCTGCGGAC
GTGCGCGAGAGCAAACGCAATCAGCGTCTCGCCATGATTAAGGAACTCGGCCCACAAGGTCTCGCTGAAAAACGCAGCAC
CAATATGTTGTCCGCGAACGCGAGCGATGAAGCGCGCGCATGGGTGCGCTGGAACATGTCGCGGGTGATCCCACGTGGCT
ATGTTCAAGCAACACATCTGCTCGCGAACGCCGATCTCGCCAGCGATCTCGCGCGCTACAAAGGCCGCATCAGCATCGCA
GTCGGCGCAGACGACGCTATCACGCCCCCCGAAGCCTGCGAGCGACTCGCCCTGACGGCCGGCACCAGGTTGCAGGTTGT
GCCGGGCGCGGGGCATGCCGGCTATATCGAAGCACCCACCGCGTACACCGCGATCATCGACACGTTCTGCCGCGCGAGCG
ACGGACAACGGAGCCAATGA

Antitoxin


Download         Length: 298 a.a.        Molecular weight: 32988.54 Da        Isoelectric Point: 6.2995

>AT249280 WP_028195929.1 NZ_CP099645:434459-435352 [Paraburkholderia fungorum]
MTPDTINAERDADDDRNDADTGSEINYRVPGLERGLKILTEFSPREPVLGAPELSKRLKIPRTTVFRLLQTLESLGFLER
ADKDRNYRLGVAVLRLGFEYLSSLELTDLGLPIIEALRNDTGLTSHIVIRDGRDVVFVAKAQSHAPIFSSVKVNVGTRLP
AYATTHGQVLMSDMTLDELKKLYPEPELERFTKQTPATVEELYERVCDDARRGYAISESSFERGISVVSAPVRNDTGRIV
AVITTTIPRPEIDASLLDSGLIDKVRRAADELSQRLNYRPKGSANGGTKYMKALGLK

Download         Length: 894 bp

>AT249280 NZ_CP099645:434459-435352 [Paraburkholderia fungorum]
ATGACGCCCGACACGATTAACGCCGAGCGCGACGCGGACGACGACCGCAACGACGCGGACACCGGCAGCGAGATCAACTA
TCGCGTGCCGGGTCTGGAACGTGGTCTGAAGATATTGACCGAATTCTCGCCGCGCGAGCCGGTTCTCGGCGCGCCGGAAC
TATCGAAGCGCCTGAAGATTCCCCGCACGACGGTGTTCCGTCTGCTGCAAACGCTCGAATCGCTCGGTTTTCTCGAGCGC
GCCGACAAAGACCGTAATTACCGCCTCGGCGTCGCGGTGCTGCGGCTCGGTTTCGAGTACCTGAGTTCGCTTGAACTGAC
CGATCTCGGGTTGCCGATCATCGAAGCCTTGCGCAACGACACCGGCCTCACCAGCCATATCGTGATTCGCGACGGACGCG
ATGTTGTGTTCGTCGCGAAGGCGCAAAGTCATGCGCCGATCTTCAGCTCGGTGAAGGTGAACGTCGGCACGCGTCTGCCG
GCTTACGCAACGACGCACGGCCAGGTGCTGATGAGCGACATGACGCTCGACGAGTTGAAAAAGCTCTATCCCGAGCCGGA
ACTGGAACGCTTCACGAAGCAAACACCCGCCACCGTCGAGGAGTTGTACGAACGGGTTTGCGATGACGCGAGGCGCGGTT
ACGCGATCAGCGAGTCGTCGTTCGAACGCGGCATTTCCGTGGTGAGCGCGCCGGTTCGCAACGACACGGGCCGTATCGTC
GCGGTGATTACGACCACGATTCCGCGTCCTGAGATCGACGCTTCGCTGCTCGACAGCGGCCTGATCGACAAGGTTCGCCG
CGCGGCCGACGAACTCTCGCAGCGGCTCAATTATCGACCGAAGGGCAGCGCGAACGGTGGCACGAAATACATGAAGGCAC
TGGGACTCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References