Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1725537..1727330 Replicon chromosome
Accession NZ_CP099629
Organism Paraburkholderia fungorum strain OTU2BAGNBA2

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NFS19_RS30385 Protein ID WP_252889489.1
Coordinates 1725537..1726436 (+) Length 300 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag NFS19_RS30390 Protein ID WP_252889488.1
Coordinates 1726437..1727330 (+) Length 298 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFS19_RS30355 (NFS19_30350) 1720887..1721963 - 1077 WP_030103722.1 porin -
NFS19_RS30360 (NFS19_30355) 1722405..1722719 + 315 WP_028195935.1 non-heme iron oxygenase ferredoxin subunit -
NFS19_RS30365 (NFS19_30360) 1722721..1723032 + 312 WP_030103723.1 hypothetical protein -
NFS19_RS30370 (NFS19_30365) 1723082..1724179 + 1098 WP_030103724.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
NFS19_RS30375 (NFS19_30370) 1724172..1724948 + 777 WP_252889490.1 SDR family oxidoreductase -
NFS19_RS30380 (NFS19_30375) 1724975..1725502 + 528 WP_216750882.1 cupin domain-containing protein -
NFS19_RS30385 (NFS19_30380) 1725537..1726436 + 900 WP_252889489.1 alpha/beta hydrolase Toxin
NFS19_RS30390 (NFS19_30385) 1726437..1727330 + 894 WP_252889488.1 IclR family transcriptional regulator Antitoxin
NFS19_RS30395 (NFS19_30390) 1727327..1728136 + 810 WP_252889487.1 SDR family oxidoreductase -
NFS19_RS30400 (NFS19_30395) 1728129..1729787 + 1659 WP_106356173.1 thiamine pyrophosphate-binding protein -
NFS19_RS30405 (NFS19_30400) 1729780..1730610 + 831 WP_106356175.1 aspartate dehydrogenase -
NFS19_RS30410 (NFS19_30405) 1730643..1732133 + 1491 WP_046572111.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(53-282)

Antitoxin

Transcription regulator IclR, N-terminal

(32-80)


Sequences

Toxin        


Download         Length: 300 a.a.        Molecular weight: 31516.63 Da        Isoelectric Point: 5.6619

>T249278 WP_252889489.1 NZ_CP099629:1725537-1726436 [Paraburkholderia fungorum]
MSAVPSRIADNVDQNATLEARLARFPAQQIWLASQRAVSYREADSAASDALPLVLLHGIGSGAASWVQQFEVLGETRCVL
AWDAPGYGASTPVEADSPAAGDYATVLKEWLDALGIERCVLLGHSLGAIVAGAFAVTNPQLVAGLLLLSPAGGYGASPAD
VRESKRNQRLAMIKELGPQGLAEKRSTNMLSANASDEARAWVRWNMSRVIPRGYVQATHLLANADLASDLARYKGHISIA
VGADDAITPPEACERLALTASTRLQVVPGAGHAGYIEAPTAYTAIIDTFCRASDGQRSQ

Download         Length: 900 bp

Antitoxin


Download         Length: 298 a.a.        Molecular weight: 33002.57 Da        Isoelectric Point: 6.2995

>AT249278 WP_252889488.1 NZ_CP099629:1726437-1727330 [Paraburkholderia fungorum]
MTPDTINAERDADDDRNDADASSEINYRVPGLERGLKILTEFSPREPVLGAPELSKRLKIPRTTVFRLLQTLESLGFLER
ADKDRNYRLGVAVLRLGFEYLSSLELTDLGLPIIEALRNDTGLTSHIVIRDGRDVVFVAKAQSHAPIFSSVKVNVGTRLP
AYATTHGQVLMSDMTLDELKKLYPEPELERFTKQTPATVEELYERVCDDARRGYAISESSFERGISVVSAPVRNDTGRIV
AVITTTIPRPEIDASLLDSGLIDKVRRAADELSQRLNYRPKGSANAGTKYMKALGLK

Download         Length: 894 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References