Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 186579..187252 Replicon chromosome
Accession NZ_CP099627
Organism Paraburkholderia fungorum strain OTU2BAGNBA2

Toxin (Protein)


Gene name vapC Uniprot ID U2HB51
Locus tag NFS19_RS00820 Protein ID WP_012431246.1
Coordinates 186579..186983 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U2H4U0
Locus tag NFS19_RS00825 Protein ID WP_012431247.1
Coordinates 186980..187252 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFS19_RS00795 (NFS19_00795) 182386..183813 + 1428 WP_012431241.1 amidase family protein -
NFS19_RS00800 (NFS19_00800) 183810..184355 + 546 WP_012431242.1 amino acid synthesis family protein -
NFS19_RS00805 (NFS19_00805) 184437..185471 + 1035 WP_012431243.1 porin -
NFS19_RS00810 (NFS19_00810) 185723..185965 + 243 WP_012431244.1 AlpA family transcriptional regulator -
NFS19_RS00815 (NFS19_00815) 185962..186288 + 327 WP_012431245.1 hypothetical protein -
NFS19_RS00820 (NFS19_00820) 186579..186983 - 405 WP_012431246.1 type II toxin-antitoxin system VapC family toxin Toxin
NFS19_RS00825 (NFS19_00825) 186980..187252 - 273 WP_012431247.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NFS19_RS00830 (NFS19_00830) 187779..188651 + 873 WP_012431248.1 ParA family protein -
NFS19_RS00835 (NFS19_00835) 188644..189228 + 585 WP_012431249.1 hypothetical protein -
NFS19_RS00840 (NFS19_00840) 189225..189902 + 678 WP_012431250.1 lytic transglycosylase domain-containing protein -
NFS19_RS00845 (NFS19_00845) 189958..190281 + 324 WP_012431251.1 TrbC/VirB2 family protein -
NFS19_RS00850 (NFS19_00850) 190295..190627 + 333 WP_012431252.1 VirB3 family type IV secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1515..215914 214399


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(16-54)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14466.86 Da        Isoelectric Point: 6.4531

>T249274 WP_012431246.1 NZ_CP099627:c186983-186579 [Paraburkholderia fungorum]
MNGYLLDTNVIRDMIRYPSGKVATHIGQIDPRAICTSVVVAAELRYGCARKGSEKLLARVESLLAIIPVLPLDVPADTEY
GGIRAELEIAGQPIGANELLIAAHACALGLTLVTDNTKVFSRIRGLAIENWLDR

Download         Length: 405 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10321.75 Da        Isoelectric Point: 4.5112

>AT249274 WP_012431247.1 NZ_CP099627:c187252-186980 [Paraburkholderia fungorum]
MPVPPPSGRPREARLFRNNRSQAVRIPVEFELPGDRVLIYREGDRLIIEPVKTPANIIELLDAWRQEPRFGPDDQFPDIE
DAPLQPEGIP

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2HB51

Antitoxin

Source ID Structure
AlphaFold DB U2H4U0

References