249271

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 81667..82269 Replicon chromosome
Accession NZ_CP099625
Organism Paraburkholderia fungorum strain OTU2BAGNBA1

Toxin (Protein)


Gene name PumA Uniprot ID A0A2N8Q3W2
Locus tag NFE55_RS23205 Protein ID WP_028194450.1
Coordinates 81970..82269 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A0D5VNN5
Locus tag NFE55_RS23200 Protein ID WP_028194449.1
Coordinates 81667..81966 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFE55_RS23180 (NFE55_23180) 76922..78232 + 1311 WP_046570534.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
NFE55_RS23185 (NFE55_23185) 78269..79525 + 1257 WP_102857553.1 hybrid-cluster NAD(P)-dependent oxidoreductase -
NFE55_RS23190 (NFE55_23190) 79668..80525 + 858 WP_028194447.1 glycine betaine ABC transporter substrate-binding protein -
NFE55_RS23195 (NFE55_23195) 80620..81495 - 876 WP_252890180.1 formyltetrahydrofolate deformylase -
NFE55_RS23200 (NFE55_23200) 81667..81966 - 300 WP_028194449.1 putative addiction module antidote protein Antitoxin
NFE55_RS23205 (NFE55_23205) 81970..82269 - 300 WP_028194450.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFE55_RS23210 (NFE55_23210) 82348..83262 - 915 WP_178370025.1 LysR family transcriptional regulator -
NFE55_RS23215 (NFE55_23215) 83415..84962 + 1548 WP_252890181.1 choline-sulfatase -
NFE55_RS23220 (NFE55_23220) 85014..85967 + 954 WP_235430069.1 choline ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 78269..83262 4993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-87)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-92)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11009.69 Da        Isoelectric Point: 9.6247

>T249271 WP_028194450.1 NZ_CP099625:c82269-81970 [Paraburkholderia fungorum]
MLKIRTTETFDAWFDGLKDRIARRRIQARIDRLAMGNPGDTNSAGAPIIELRIDHGPGYRVYYVQRGAVLVILLCGGDKS
TQPADIKAAHKMLANLESE

Download         Length: 300 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10603.11 Da        Isoelectric Point: 6.0723

>AT249271 WP_028194449.1 NZ_CP099625:c81966-81667 [Paraburkholderia fungorum]
MGKIKTRPWDSAEHLKTEADMAEYFEACLVEGGDDPAFLAHALGVIARARGMAQLARDTGISREGLYKALSEDGNPSFAT
IIKVIRALGLELHAAPAHA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N8Q3W2

Antitoxin

Source ID Structure
AlphaFold DB A0A0D5VNN5

References