249270

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4717736..4718325 Replicon chromosome
Accession NZ_CP099623
Organism Paraburkholderia fungorum strain OTU2BAGNBA1

Toxin (Protein)


Gene name hicA Uniprot ID A0A1I7EHY9
Locus tag NFE55_RS21165 Protein ID WP_028198502.1
Coordinates 4717736..4717918 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0D5V779
Locus tag NFE55_RS21170 Protein ID WP_028198501.1
Coordinates 4717915..4718325 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFE55_RS21135 (NFE55_21135) 4712821..4713510 - 690 WP_235429695.1 flagellar hook assembly protein FlgD -
NFE55_RS21140 (NFE55_21140) 4713578..4714003 - 426 WP_028198507.1 flagellar basal body rod protein FlgC -
NFE55_RS21145 (NFE55_21145) 4714174..4714668 - 495 WP_028198506.1 flagellar basal body rod protein FlgB -
NFE55_RS21150 (NFE55_21150) 4714886..4716346 + 1461 WP_252888526.1 flagellar basal body P-ring formation chaperone FlgA -
NFE55_RS21155 (NFE55_21155) 4716530..4716886 + 357 WP_028198504.1 flagellar biosynthesis anti-sigma factor FlgM -
NFE55_RS21160 (NFE55_21160) 4716981..4717427 + 447 WP_028198503.1 flagellar protein FlgN -
NFE55_RS21165 (NFE55_21165) 4717736..4717918 + 183 WP_028198502.1 type II toxin-antitoxin system HicA family toxin Toxin
NFE55_RS21170 (NFE55_21170) 4717915..4718325 + 411 WP_028198501.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFE55_RS21175 (NFE55_21175) 4718390..4719130 - 741 WP_028198500.1 RNA polymerase sigma factor FliA -
NFE55_RS21180 (NFE55_21180) 4719159..4720028 - 870 WP_028198499.1 P-loop NTPase -
NFE55_RS21185 (NFE55_21185) 4720021..4721952 - 1932 WP_252888527.1 flagellar biosynthesis protein FlhF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6569.73 Da        Isoelectric Point: 11.3940

>T249270 WP_028198502.1 NZ_CP099623:4717736-4717918 [Paraburkholderia fungorum]
MNSAEVVKVIQADGWRLIRISGSHHHFRHAVKAGLVTIPHPKKDLPPGTLNSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14824.81 Da        Isoelectric Point: 4.9474

>AT249270 WP_028198501.1 NZ_CP099623:4717915-4718325 [Paraburkholderia fungorum]
MKNLIFPIAIEPGDTHHAFGVIVPDIPGCHSAGSSLEEAYANAKEAIEAHLDTLLDEGLPIPERLTLEEHRRNPDYAGFT
WGFVTTRNIPALKKAVRINISLPEALVHDIDAYAQARGMSRSAFLALAAEHEMADA

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I7EHY9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D5V779

References