Detailed information of TA system TA024926

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1422538..1424099
• Replicon: chromosome
• Accession: NC_014562
• Organism: Pantoea vagans C9-1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: E1SDG3
• Locus tag: PVAG_RS10670
• Protein ID: WP_013357881.1
• Coordinates: 1422538..1423851 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: PVAG_RS10675
• Protein ID: WP_013357882.1
• Coordinates: 1423851..1424099 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PVAG_RS10650	1417694..1419739	-	2046	WP_013357877.1	FUSC family protein	-
PVAG_RS10655	1419889..1420533	-	645	WP_013357878.1	LysE family translocator	-
PVAG_RS10660	1420614..1421996	-	1383	WP_013357879.1	M24 family metallopeptidase	-
PVAG_RS10665	1422227..1422433	-	207	WP_013357880.1	type II toxin-antitoxin system MqsA family antitoxin	-
PVAG_RS10670	1422538..1423851	-	1314	WP_013357881.1	type II toxin-antitoxin system HipA family toxin	Toxin
PVAG_RS10675	1423851..1424099	-	249	WP_013357882.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
PVAG_RS10680	1424279..1424716	+	438	WP_013357883.1	GNAT family N-acetyltransferase	-
PVAG_RS10685	1424750..1425541	-	792	WP_013357884.1	inositol monophosphatase family protein	-
PVAG_RS10690	1425565..1426626	-	1062	WP_013357885.1	ABC transporter ATP-binding protein	-
PVAG_RS10695	1426623..1428848	-	2226	WP_013357886.1	iron ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49275.78 Da
• Isoelectric Point: 8.4318

>T24926 WP_013357881.1 NC_014562:c1423851-1422538 [Pantoea vagans C9-1]
MQRLIAWMNGERVGVLTRQRNGAHEFQYDTGWLSNPLSRPLSLSLPLQVKAITSHAVINFFDNLLPDSPLIRDRIVARYQ
IKSRQPFDLLQEVGRDSVGATMLLPPDMPLPALQARYEVLDEARLESVLSAYQSDIPLGMLREETDFRISVAGAQEKTAL
LLTEEGWSIPAGATPTSHIIKLPIGEIKQPAATLDMRESVENEYLCLALARAMGIDVPQATIIRAGKMRALAVERFDRRW
SRDRTRLIRLPQEDFCQALGLPSSTKYESDGGPGIAEIMQILMGSSNAIEDRYRFMMFQVFQWLTGATDGHAKNFSLFIE
RGGSYRLTPFYDVISAYPVLGGTGLNRRALKLAMGLRATKGKKTEIDKIFPRHFIATAKQVNFDRDSLQQIFDFFVREFP
KAVVSVREALPADFPQHIADAIFSHSLIMLERLRHND

Nucleotide

• Length: 1314 bp

>T24926 NC_014562:c1423851-1422538 [Pantoea vagans C9-1]
ATGCAAAGGCTGATTGCGTGGATGAACGGTGAGCGGGTAGGCGTGCTTACCCGGCAGCGAAACGGCGCTCATGAGTTTCA
GTATGATACCGGCTGGCTGAGTAACCCGCTCTCCAGGCCGCTGTCACTCTCACTGCCGCTGCAGGTTAAGGCGATTACCT
CACACGCCGTAATTAACTTTTTCGACAACCTGCTGCCGGATAGCCCGTTGATTCGTGACAGGATCGTGGCGCGTTACCAG
ATTAAATCCCGCCAGCCGTTTGACCTGTTGCAGGAAGTGGGACGTGACAGCGTCGGAGCGACCATGCTGTTGCCGCCCGA
TATGCCGCTGCCCGCACTGCAGGCTCGCTATGAGGTGCTTGATGAAGCCCGGCTCGAGAGCGTGCTGTCAGCCTATCAGT
CCGATATTCCGCTGGGGATGCTGCGTGAAGAGACCGACTTCCGCATTTCGGTGGCGGGCGCACAGGAGAAAACGGCGCTG
CTGCTGACCGAAGAGGGCTGGAGCATTCCTGCCGGCGCTACGCCCACCTCACACATTATCAAGCTGCCAATCGGTGAGAT
TAAACAGCCAGCCGCGACGCTGGATATGCGTGAAAGCGTAGAGAATGAGTATCTCTGTCTGGCGCTGGCACGTGCAATGG
GTATTGATGTGCCGCAGGCGACGATTATCCGGGCCGGTAAGATGCGCGCTCTGGCCGTTGAGCGCTTCGACCGCCGCTGG
TCGCGCGACCGAACCCGGCTGATTCGTCTGCCACAGGAGGATTTCTGTCAGGCGCTGGGGCTGCCATCCTCGACTAAATA
TGAGTCGGATGGCGGGCCGGGCATCGCAGAAATAATGCAGATACTGATGGGATCGAGCAATGCCATCGAGGATCGCTATC
GCTTTATGATGTTCCAGGTGTTCCAGTGGCTGACGGGCGCAACCGACGGTCACGCTAAAAACTTCTCGCTGTTTATCGAG
CGCGGCGGCAGTTATCGACTGACACCCTTTTATGATGTGATCTCCGCTTATCCGGTGCTGGGCGGTACCGGCCTGAACAG
GCGTGCACTCAAACTGGCGATGGGGCTGCGTGCCACTAAGGGGAAGAAGACAGAAATCGACAAAATCTTTCCGCGCCATT
TTATCGCCACGGCGAAGCAGGTGAATTTTGATCGTGACAGCCTGCAACAGATCTTTGACTTCTTCGTCCGTGAGTTTCCA
AAGGCGGTAGTCTCAGTGCGCGAGGCATTACCGGCCGATTTCCCGCAGCACATCGCGGATGCAATCTTCAGCCATTCACT
GATTATGCTGGAGCGGTTACGGCATAACGATTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9280.52 Da
• Isoelectric Point: 5.0637

>AT24926 WP_013357882.1 NC_014562:c1424099-1423851 [Pantoea vagans C9-1]
MIYSPLQLANRLKLIRQRNGWTQSELAKKVGLKQATISHFENAPDSTSLATLFKLLQALEVSLDVVEKEEASASQLHDED
EW

Nucleotide

• Length: 249 bp

>AT24926 NC_014562:c1424099-1423851 [Pantoea vagans C9-1]
ATGATATACAGCCCGCTACAGCTGGCAAACCGGCTAAAGCTTATCCGCCAGCGCAACGGCTGGACCCAGAGTGAACTGGC
AAAAAAGGTGGGCCTGAAACAGGCAACCATCTCTCACTTTGAAAATGCGCCTGACAGTACCTCGCTGGCCACGCTGTTTA
AGCTTTTACAGGCGCTGGAAGTGAGTCTGGACGTAGTGGAAAAAGAGGAGGCCAGTGCGTCTCAGTTGCATGATGAGGAT
GAATGGTAA

Structures

Toxin

• AlphaFold DB: E1SDG3