Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 429799..430416 Replicon chromosome
Accession NC_014562
Organism Pantoea vagans C9-1

Toxin (Protein)


Gene name Hha Uniprot ID E0LTU7
Locus tag PVAG_RS05900 Protein ID WP_003850458.1
Coordinates 429799..430014 (-) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E1SGC9
Locus tag PVAG_RS05905 Protein ID WP_013357010.1
Coordinates 430039..430416 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVAG_RS05875 425701..426039 + 339 WP_003850469.1 P-II family nitrogen regulator -
PVAG_RS05880 426074..427360 + 1287 WP_013357006.1 ammonium transporter AmtB -
PVAG_RS05885 427419..428282 - 864 WP_013357007.1 acyl-CoA thioesterase II -
PVAG_RS05890 428473..429030 + 558 WP_013357008.1 YbaY family lipoprotein -
PVAG_RS05895 429032..429376 - 345 WP_013357009.1 MGMT family protein -
PVAG_RS05900 429799..430014 - 216 WP_003850458.1 hemolysin expression modulator Hha Toxin
PVAG_RS05905 430039..430416 - 378 WP_013357010.1 Hha toxicity modulator TomB Antitoxin
PVAG_RS05910 430564..430917 - 354 WP_041456682.1 hypothetical protein -
PVAG_RS05915 431247..431915 + 669 WP_013357011.1 ABC transporter ATP-binding protein -
PVAG_RS05920 431912..432751 + 840 WP_041456684.1 metal ABC transporter permease -
PVAG_RS05925 432771..433649 + 879 WP_013357013.1 metal ABC transporter substrate-binding protein -
PVAG_RS22905 433695..433835 - 141 WP_009091664.1 type B 50S ribosomal protein L36 -
PVAG_RS05930 433847..434101 - 255 WP_013357014.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8510.90 Da        Isoelectric Point: 9.4825

>T24925 WP_003850458.1 NC_014562:c430014-429799 [Pantoea vagans C9-1]
MNKTLTKTDYLMRLRRCRSLDTLERVIEKNKYELPEDELAVFYSAADHRLAELTMNKLYDKVPGSVWKFVR

Download         Length: 216 bp

>T24925 NC_014562:c430014-429799 [Pantoea vagans C9-1]
ATGAACAAAACCCTGACTAAAACCGATTATTTGATGCGACTGCGGCGTTGCCGCTCTCTGGATACCCTGGAAAGGGTCAT
TGAAAAAAATAAGTATGAATTACCCGAGGATGAATTAGCGGTATTTTACTCTGCAGCTGACCATCGCCTGGCGGAACTGA
CGATGAACAAGCTTTATGATAAAGTCCCAGGTTCAGTATGGAAATTTGTCCGCTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14650.28 Da        Isoelectric Point: 4.3976

>AT24925 WP_013357010.1 NC_014562:c430416-430039 [Pantoea vagans C9-1]
MDEYSPKRHDIAQLKYLCESLFDDSMATLTDSHHGWVNDPTSESNLQLNDLIEHIASFTMNYKIKHVEDEALISQIDEYL
DDTFMLFSNYGINSPDLQRWQRSAKRLFNLFTEECAFLQQPSHSL

Download         Length: 378 bp

>AT24925 NC_014562:c430416-430039 [Pantoea vagans C9-1]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATATCTGTGTGAGAGCCTGTTTGACGACAGCATGGC
AACATTAACCGACAGCCATCACGGCTGGGTGAACGACCCCACTTCTGAAAGCAATCTGCAGCTTAACGATTTGATTGAAC
ACATTGCCTCTTTCACCATGAATTACAAAATTAAGCACGTTGAAGATGAAGCGCTGATTTCGCAAATCGATGAATATCTT
GATGATACTTTTATGCTATTCAGCAACTATGGTATCAATAGTCCGGATCTTCAACGGTGGCAACGTTCAGCAAAACGCTT
ATTTAATCTGTTCACTGAAGAGTGCGCTTTTCTCCAGCAACCAAGCCATTCATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I5AGC3

Antitoxin

Source ID Structure
AlphaFold DB A0A5M7PH97

References