Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 5903144..5904768 Replicon chromosome
Accession NZ_CP099608
Organism Pseudomonas moraviensis strain OTU5BARRA1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NF672_RS26345 Protein ID WP_065616399.1
Coordinates 5903419..5904768 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NF672_RS26340 Protein ID WP_252873598.1
Coordinates 5903144..5903422 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF672_RS26310 (NF672_26310) 5898575..5899198 + 624 WP_116657239.1 FMN-binding negative transcriptional regulator -
NF672_RS26315 (NF672_26315) 5899209..5899655 + 447 WP_252873595.1 GNAT family N-acetyltransferase -
NF672_RS26320 (NF672_26320) 5899668..5900339 + 672 WP_116657237.1 GNAT family protein -
NF672_RS26325 (NF672_26325) 5900461..5901363 - 903 WP_252873596.1 homocysteine S-methyltransferase family protein -
NF672_RS26330 (NF672_26330) 5901477..5902295 + 819 WP_252873597.1 ABC transporter substrate-binding protein -
NF672_RS26335 (NF672_26335) 5902292..5903128 + 837 WP_065616398.1 amino acid ABC transporter permease -
NF672_RS26340 (NF672_26340) 5903144..5903422 - 279 WP_252873598.1 helix-turn-helix transcriptional regulator Antitoxin
NF672_RS26345 (NF672_26345) 5903419..5904768 - 1350 WP_065616399.1 HipA domain-containing protein Toxin
NF672_RS26350 (NF672_26350) 5905138..5907333 + 2196 WP_252873599.1 autotransporter outer membrane beta-barrel domain-containing protein -
NF672_RS26355 (NF672_26355) 5907528..5909336 - 1809 WP_042608049.1 sodium-extruding oxaloacetate decarboxylase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-367)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-82)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 49805.33 Da        Isoelectric Point: 5.0718

>T249249 WP_065616399.1 NZ_CP099608:c5904768-5903419 [Pseudomonas moraviensis]
MYNLTLQVFTAGQWHDAMTLDFDDPEKGFESRCSFGYEAGYLVENIELIGSPFSQAVSALYPLDWEGRRAKTPAFVHDIA
PAGAAKRFLLARLGQERPAEISADLFLLGRRTPAPIGNMRIKESAEAVDERKPIGFKREEVISRDNRFLEYAYELGAAIG
GATGAGGEAPKLLLAENSAGLLYPDAVLDDEEVRQHWFVKFARNRGGQTDQDILRSEFHYYKALQTLGIETVAAEGLALE
EANKPSLWMRRFDRQVEDGAVSRFAVESIYSLAEVTTPGSAMNHLDVIRMLAGLWRKAGQASQIPGLVADYLRRDLINKI
LGNSDNHGRNTAIIRQENAFQLAPIYDLAPMVMDDEGVTRTTKWPKELERAGDVDWRGVCRVLADSADPHDSLAGLDASA
LFEGLRADARRLAALPDILAASGLPARTMNHPSVHLKNLEQRLKEWDLQ

Download         Length: 1350 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10304.06 Da        Isoelectric Point: 10.7364

>AT249249 WP_252873598.1 NZ_CP099608:c5903422-5903144 [Pseudomonas moraviensis]
MSLTVLERTALIESIQQSLAEGTLEIGDAVRRLRVEVTGLHQSQFAKMCKISVRTLVHIEHGEGNQTLKSLNAVFRPFGM
KMGVVRIRRDTV

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References