249242

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1732545..1733584 Replicon chromosome
Accession NZ_CP099608
Organism Pseudomonas moraviensis strain OTU5BARRA1

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A2U1R6X1
Locus tag NF672_RS07610 Protein ID WP_042607561.1
Coordinates 1732545..1733120 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A2U1R6T9
Locus tag NF672_RS07615 Protein ID WP_042607562.1
Coordinates 1733117..1733584 (-) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF672_RS07585 (NF672_07585) 1727886..1729874 + 1989 WP_064365458.1 heme lyase CcmF/NrfE family subunit -
NF672_RS07590 (NF672_07590) 1729871..1730407 + 537 WP_064365457.1 DsbE family thiol:disulfide interchange protein -
NF672_RS07595 (NF672_07595) 1730404..1730874 + 471 WP_064365456.1 cytochrome c-type biogenesis protein CcmH -
NF672_RS07600 (NF672_07600) 1730871..1732070 + 1200 WP_042607559.1 c-type cytochrome biogenesis protein CcmI -
NF672_RS07605 (NF672_07605) 1732096..1732500 + 405 WP_064365455.1 hypothetical protein -
NF672_RS07610 (NF672_07610) 1732545..1733120 - 576 WP_042607561.1 PIN domain-containing protein Toxin
NF672_RS07615 (NF672_07615) 1733117..1733584 - 468 WP_042607562.1 helix-turn-helix domain-containing protein Antitoxin
NF672_RS07620 (NF672_07620) 1733769..1733981 + 213 WP_042607563.1 type II toxin-antitoxin system HicA family toxin -
NF672_RS07625 (NF672_07625) 1733981..1734385 + 405 WP_064365452.1 type II toxin-antitoxin system HicB family antitoxin -
NF672_RS07630 (NF672_07630) 1734498..1735697 - 1200 WP_252874094.1 MFS transporter -
NF672_RS07635 (NF672_07635) 1736106..1737104 - 999 WP_042607566.1 sulfate ABC transporter substrate-binding protein -
NF672_RS07640 (NF672_07640) 1737281..1738105 - 825 WP_064365449.1 ion transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21608.64 Da        Isoelectric Point: 5.8606

>T249242 WP_042607561.1 NZ_CP099608:c1733120-1732545 [Pseudomonas moraviensis]
VRHSSFTAVYDACVLYPAPLRDFLMWLALSGLYRARWTQEIHHEWKRNLLKNRSDLTLEQLDRTSQLMDLAIPDACIDGY
EDLVSGLTLPDENDRHVLAAAIRCGADVIVTFNLKDFPSCHLAPYGIEAQHPDEFVENLFHLDSAAVVAAAQSQRRQLKT
PTVEVDKYLGFLQRQGLVESVKALGNYRAIL

Download         Length: 576 bp

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17223.59 Da        Isoelectric Point: 6.0020

>AT249242 WP_042607562.1 NZ_CP099608:c1733584-1733117 [Pseudomonas moraviensis]
MPTPIPSTTNLPVEREVKAAIEGQRTLTAFLATGFDTQRIQIFDEQNEAHSVELPTSALRLLSDILAALAEGNAVKVVPI
HAELTTQEAADLLNVSRPHMIKLLESGEISYHKTGKHRRVRFADLMEYKTRRDTASEQAMTLLAEQAQALRTGYE

Download         Length: 468 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U1R6X1

Antitoxin

Source ID Structure
AlphaFold DB A0A2U1R6T9

References