249239

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 5830138..5831762 Replicon chromosome
Accession NZ_CP099602
Organism Pseudomonas siliginis strain OTU6MONTID1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NF680_RS26200 Protein ID WP_252877139.1
Coordinates 5830413..5831762 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A554AI87
Locus tag NF680_RS26195 Protein ID WP_041476582.1
Coordinates 5830138..5830416 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF680_RS26165 (NF680_26165) 5825576..5826199 + 624 WP_252877136.1 FMN-binding negative transcriptional regulator -
NF680_RS26170 (NF680_26170) 5826210..5826656 + 447 WP_236167797.1 GNAT family N-acetyltransferase -
NF680_RS26175 (NF680_26175) 5826669..5827340 + 672 WP_056790955.1 GNAT family protein -
NF680_RS26180 (NF680_26180) 5827463..5828365 - 903 WP_252877137.1 homocysteine S-methyltransferase family protein -
NF680_RS26185 (NF680_26185) 5828479..5829297 + 819 WP_252877138.1 ABC transporter substrate-binding protein -
NF680_RS26190 (NF680_26190) 5829294..5830130 + 837 WP_122698746.1 amino acid ABC transporter permease -
NF680_RS26195 (NF680_26195) 5830138..5830416 - 279 WP_041476582.1 helix-turn-helix transcriptional regulator Antitoxin
NF680_RS26200 (NF680_26200) 5830413..5831762 - 1350 WP_252877139.1 HipA domain-containing protein Toxin
NF680_RS26205 (NF680_26205) 5831942..5832229 + 288 WP_252878200.1 hypothetical protein -
NF680_RS26210 (NF680_26210) 5832132..5834321 + 2190 WP_252877140.1 autotransporter outer membrane beta-barrel domain-containing protein -
NF680_RS26215 (NF680_26215) 5834530..5836338 - 1809 WP_252877141.1 sodium-extruding oxaloacetate decarboxylase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-367)

Antitoxin

Cro/C1-type helix-turn-helix domain

(27-80)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 49792.41 Da        Isoelectric Point: 5.1539

>T249239 WP_252877139.1 NZ_CP099602:c5831762-5830413 [Pseudomonas siliginis]
MYNLTLQIFTAGQWHDAMILDFDDPEKGFESRCSFGYEADYLVENIELIGSPFSQAVSALYPLDWEGRRAKTPAFVHDIA
PAGAAKRFLLARLGQERPAEISADLFLLGRSTPAPIGNMRIKESAEAVDDRKPIGFKREEVISRDNRFLEYAYELGAAIG
GATGAGGEAPKLLLAENSAGLLYPDAVLDDEEVRQHWFVKFARNRGGQTDQDILRSEFHYYKALQTLGIATVAAEGLALE
EATKPSLWMRRFDRQVKDGAVSRFAVESIYSLAEVTTPGSAMNHLEVIRMLAGLWRKAGQASQIPGLVADYLRRDLINKI
LGNSDNHGRNTAIIRQENAFQLAPIYDLAPMVMDDEGVTRTTKWPKELERAGDVDWRGVCRVLADSADPHESLTGLDASA
LFEGLRADARRLAALPDILAASGLPARTMNHPSVHLKNLEQRLKEWDLQ

Download         Length: 1350 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10332.12 Da        Isoelectric Point: 10.7364

>AT249239 WP_041476582.1 NZ_CP099602:c5830416-5830138 [Pseudomonas siliginis]
MSLTVLERTALIESIQQSLAEGTLEIGDAVRRLRVEVTGLHQTQFAKMCKISVRTLVHIEHGEGNQTLKSLNAVFRPFGM
KMGVVRIRRDTI

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A554AI87

References