Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1723955..1724571 Replicon chromosome
Accession NZ_CP099601
Organism Pseudomonas siliginis strain OTU6MONEA1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NF679_RS07585 Protein ID WP_041479616.1
Coordinates 1723955..1724167 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NF679_RS07590 Protein ID WP_252869018.1
Coordinates 1724167..1724571 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF679_RS07555 (NF679_07555) 1720057..1720593 + 537 WP_024012128.1 DsbE family thiol:disulfide interchange protein -
NF679_RS07560 (NF679_07560) 1720590..1721060 + 471 WP_252869016.1 cytochrome c-type biogenesis protein CcmH -
NF679_RS07565 (NF679_07565) 1721057..1722256 + 1200 WP_056783853.1 c-type cytochrome biogenesis protein CcmI -
NF679_RS07570 (NF679_07570) 1722282..1722686 + 405 WP_252869017.1 hypothetical protein -
NF679_RS07575 (NF679_07575) 1722732..1723306 - 575 Protein_1494 PIN domain-containing protein -
NF679_RS07580 (NF679_07580) 1723303..1723770 - 468 WP_056783858.1 helix-turn-helix domain-containing protein -
NF679_RS07585 (NF679_07585) 1723955..1724167 + 213 WP_041479616.1 type II toxin-antitoxin system HicA family toxin Toxin
NF679_RS07590 (NF679_07590) 1724167..1724571 + 405 WP_252869018.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NF679_RS07595 (NF679_07595) 1724684..1725883 - 1200 WP_252869019.1 MFS transporter -
NF679_RS07600 (NF679_07600) 1726050..1727048 - 999 WP_056783861.1 sulfate ABC transporter substrate-binding protein -
NF679_RS07605 (NF679_07605) 1727153..1727977 - 825 WP_252869020.1 ion transporter -
NF679_RS07610 (NF679_07610) 1727999..1728913 - 915 WP_252869021.1 urea transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7960.12 Da        Isoelectric Point: 10.5523

>T249225 WP_041479616.1 NZ_CP099601:1723955-1724167 [Pseudomonas siliginis]
VQSRLLMKELEEAGWTLDRVAGSHYIFTHRYNPNTIAVPHPKKDLPLGTVKSIRRRAGLFSPPTRHEGDP

Download         Length: 213 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14802.84 Da        Isoelectric Point: 4.4537

>AT249225 WP_252869018.1 NZ_CP099601:1724167-1724571 [Pseudomonas siliginis]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDSFEEAYNAAVEVAYLMLQEIAAAGQAIPMPTSAAAHRNHPDFAEMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRY

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References