Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 5903569..5905193 Replicon chromosome
Accession NZ_CP099599
Organism Pseudomonas siliginis strain OTU6ESPEB1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NF677_RS26550 Protein ID WP_122698747.1
Coordinates 5903844..5905193 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NF677_RS26545 Protein ID WP_039757273.1
Coordinates 5903569..5903847 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF677_RS26515 (NF677_26515) 5899007..5899630 + 624 WP_252885040.1 FMN-binding negative transcriptional regulator -
NF677_RS26520 (NF677_26520) 5899641..5900087 + 447 WP_252885041.1 GNAT family N-acetyltransferase -
NF677_RS26525 (NF677_26525) 5900100..5900771 + 672 WP_252885042.1 GNAT family protein -
NF677_RS26530 (NF677_26530) 5900894..5901796 - 903 WP_252885043.1 homocysteine S-methyltransferase family protein -
NF677_RS26535 (NF677_26535) 5901910..5902728 + 819 WP_016772458.1 ABC transporter substrate-binding protein -
NF677_RS26540 (NF677_26540) 5902725..5903561 + 837 WP_056790962.1 amino acid ABC transporter permease -
NF677_RS26545 (NF677_26545) 5903569..5903847 - 279 WP_039757273.1 helix-turn-helix transcriptional regulator Antitoxin
NF677_RS26550 (NF677_26550) 5903844..5905193 - 1350 WP_122698747.1 HipA domain-containing protein Toxin
NF677_RS26555 (NF677_26555) 5905564..5907753 + 2190 WP_252885044.1 autotransporter outer membrane beta-barrel domain-containing protein -
NF677_RS26560 (NF677_26560) 5907964..5909772 - 1809 WP_083353857.1 sodium-extruding oxaloacetate decarboxylase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-367)

Antitoxin

Cro/C1-type helix-turn-helix domain

(27-80)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 49765.43 Da        Isoelectric Point: 5.0667

>T249214 WP_122698747.1 NZ_CP099599:c5905193-5903844 [Pseudomonas siliginis]
MYNLTLQIFTAGQWLDAMILDFDDPEKGFESRCSFGYEADYLVENIELIGSPFSQAVSALYPLDWEGRRAKTPAFVHDIA
PAGAAKRFLLARLGQERPAEISADLFLLGRSTPAPIGNMRIKESAEAVDERKPIGFKREEVISRDNRFLEYAYELGAAIG
GATGAGGEAPKLLLAENSAGLLYPDAVLDDEEVRQHWFVKFARNRGGQTDQDILRSEFHYYKALQTLGIATVAAEGLALE
EATKPSLWMRRFDRQVKDGAVSRFAVESIYSLAEVTTPGSAMNHLEVIRMLAGLWRKAGQASQIPGLVADYLRRDLINKI
LGNSDNHGRNTAIIRQENAFQLAPIYDLAPMVMDDEGVTRTTKWPKELERAGDVDWRGVCRVLADNADPHDSLAGLDASA
LFEGLRADARRLAALPDILAASGLPARTMNHPSVHLKNLEQRLKEWDLQ

Download         Length: 1350 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10316.12 Da        Isoelectric Point: 10.7364

>AT249214 WP_039757273.1 NZ_CP099599:c5903847-5903569 [Pseudomonas siliginis]
MSLTVLERTALIESIQQALAEGTLEIGDAVRRLRVEVTGLHQTQFAKMCKISVRTLVHIEHGEGNQTLKSLNAVFRPFGM
KMGVVRIRRDTI

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References