Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 5906843..5908467 Replicon chromosome
Accession NZ_CP099598
Organism Pseudomonas siliginis strain OTU6BANIB1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NF676_RS27185 Protein ID WP_252887032.1
Coordinates 5907118..5908467 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A554AI87
Locus tag NF676_RS27180 Protein ID WP_041476582.1
Coordinates 5906843..5907121 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF676_RS27150 (NF676_27155) 5902281..5902904 + 624 WP_252887030.1 FMN-binding negative transcriptional regulator -
NF676_RS27155 (NF676_27160) 5902915..5903361 + 447 WP_095181207.1 GNAT family N-acetyltransferase -
NF676_RS27160 (NF676_27165) 5903374..5904045 + 672 WP_056790955.1 GNAT family protein -
NF676_RS27165 (NF676_27170) 5904168..5905070 - 903 WP_056790957.1 homocysteine S-methyltransferase family protein -
NF676_RS27170 (NF676_27175) 5905184..5906002 + 819 WP_016772458.1 ABC transporter substrate-binding protein -
NF676_RS27175 (NF676_27180) 5905999..5906835 + 837 WP_252887031.1 amino acid ABC transporter permease -
NF676_RS27180 (NF676_27185) 5906843..5907121 - 279 WP_041476582.1 helix-turn-helix transcriptional regulator Antitoxin
NF676_RS27185 (NF676_27190) 5907118..5908467 - 1350 WP_252887032.1 HipA domain-containing protein Toxin
NF676_RS27190 (NF676_27195) 5908838..5911024 + 2187 WP_252887033.1 autotransporter outer membrane beta-barrel domain-containing protein -
NF676_RS27195 (NF676_27200) 5911234..5913042 - 1809 WP_252887034.1 sodium-extruding oxaloacetate decarboxylase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-367)

Antitoxin

Cro/C1-type helix-turn-helix domain

(27-80)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 49706.27 Da        Isoelectric Point: 5.0609

>T249207 WP_252887032.1 NZ_CP099598:c5908467-5907118 [Pseudomonas siliginis]
MYNLTLQIFTAGQWHDAMILDFDDPEKGFESRCSFGYEADYLVENIELIGSPFSQAVSALYPLDWEGRRAKTPAFVHDIA
PAGAAKRFLLARLGQERPAEISADLFLLGRSTPAPIGNMRIKESAEAVDDRKPIGFKREEVISRDNRFLEYAYELGAAIG
GATGAGGEAPKLLLAENSAGLLYPDAVLDDEEVRQHWFVKFARNRGGQTDQDILRSEFHYYKALQTLGIATVAAEGLALE
EATKPSLWMRRFDRQVKDGAVSRFAVESIYSLAEVTTPGSAMNHLEVIRMLAGLWSKAGQASQIPGLVADYLRRDLINKI
LGNSDNHGRNTAIIRQENAFQLAPIYDLAPMVMDDEGVTRTTKWPKELERAGDVDWRGVCRVLADNADPHDSLAGLDASA
LFEGLRADARRLAALPDILAASGLPARTMNHPSVHLKNLEQRLKEWDLQ

Download         Length: 1350 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10332.12 Da        Isoelectric Point: 10.7364

>AT249207 WP_041476582.1 NZ_CP099598:c5907121-5906843 [Pseudomonas siliginis]
MSLTVLERTALIESIQQSLAEGTLEIGDAVRRLRVEVTGLHQTQFAKMCKISVRTLVHIEHGEGNQTLKSLNAVFRPFGM
KMGVVRIRRDTI

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A554AI87

References