Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 358401..359029 Replicon chromosome
Accession NZ_CP099598
Organism Pseudomonas siliginis strain OTU6BANIB1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NF676_RS02210 Protein ID WP_016772140.1
Coordinates 358401..358799 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V8RDT4
Locus tag NF676_RS02215 Protein ID WP_024011210.1
Coordinates 358799..359029 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF676_RS02190 (NF676_02190) 354075..354770 - 696 WP_041477511.1 ABC transporter permease -
NF676_RS02195 (NF676_02195) 354848..355600 - 753 WP_150741763.1 ABC transporter substrate-binding protein -
NF676_RS02200 (NF676_02200) 355614..356387 - 774 WP_236168220.1 ABC transporter ATP-binding protein -
NF676_RS02205 (NF676_02205) 356931..358322 + 1392 WP_016772141.1 GABA permease -
NF676_RS02210 (NF676_02210) 358401..358799 - 399 WP_016772140.1 tRNA(fMet)-specific endonuclease VapC Toxin
NF676_RS02215 (NF676_02215) 358799..359029 - 231 WP_024011210.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NF676_RS02220 (NF676_02220) 359195..359647 - 453 WP_056787197.1 hypothetical protein -
NF676_RS02225 (NF676_02225) 359654..360067 - 414 WP_236168218.1 hypothetical protein -
NF676_RS02230 (NF676_02230) 360097..360999 - 903 WP_252887942.1 alpha/beta fold hydrolase -
NF676_RS02235 (NF676_02235) 361139..362197 - 1059 WP_095181074.1 PDDEXK nuclease domain-containing protein -
NF676_RS02240 (NF676_02240) 362477..362821 - 345 WP_056787206.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14547.92 Da        Isoelectric Point: 7.1340

>T249201 WP_016772140.1 NZ_CP099598:c358799-358401 [Pseudomonas siliginis]
MIKYMLDTNICIFTIKNKPQIVREAFNRHSGQLCISAITLMELIYGAEKSAAPEKNLAIVEGFVARLDVLPFDNDAAAQA
GMVRSELAKAGTPIGPYDQMIAGHARSLGLIVVTNNVREFQRVSGLRIEDWV

Download         Length: 399 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8588.62 Da        Isoelectric Point: 4.5203

>AT249201 WP_024011210.1 NZ_CP099598:c359029-358799 [Pseudomonas siliginis]
MEQTTIFMSNRSQAVRLPKAVAMPGDVKRVEVIAIGRTRVITPAGESWDSWFDGDSVSPDFMANREQPTEQERESF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V8RDT4

References