249198

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 5919787..5921411 Replicon chromosome
Accession NZ_CP099596
Organism Pseudomonas siliginis strain OTU6BAGNBB1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NF675_RS26200 Protein ID WP_252879128.1
Coordinates 5920062..5921411 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NF675_RS26195 Protein ID WP_150637202.1
Coordinates 5919787..5920065 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF675_RS26165 (NF675_26165) 5915225..5915848 + 624 WP_252879126.1 FMN-binding negative transcriptional regulator -
NF675_RS26170 (NF675_26170) 5915859..5916305 + 447 WP_056790952.1 GNAT family N-acetyltransferase -
NF675_RS26175 (NF675_26175) 5916318..5916989 + 672 WP_056790955.1 GNAT family protein -
NF675_RS26180 (NF675_26180) 5917112..5918014 - 903 WP_252879127.1 homocysteine S-methyltransferase family protein -
NF675_RS26185 (NF675_26185) 5918128..5918946 + 819 WP_016772458.1 ABC transporter substrate-binding protein -
NF675_RS26190 (NF675_26190) 5918943..5919779 + 837 WP_122698746.1 amino acid ABC transporter permease -
NF675_RS26195 (NF675_26195) 5919787..5920065 - 279 WP_150637202.1 helix-turn-helix transcriptional regulator Antitoxin
NF675_RS26200 (NF675_26200) 5920062..5921411 - 1350 WP_252879128.1 HipA domain-containing protein Toxin
NF675_RS26205 (NF675_26205) 5921782..5924001 + 2220 WP_252879129.1 autotransporter outer membrane beta-barrel domain-containing protein -
NF675_RS26210 (NF675_26210) 5924213..5926021 - 1809 WP_083353857.1 sodium-extruding oxaloacetate decarboxylase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-367)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-82)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 49879.45 Da        Isoelectric Point: 4.9909

>T249198 WP_252879128.1 NZ_CP099596:c5921411-5920062 [Pseudomonas siliginis]
MYNLTLQIFTAGQWHDAMILDFDDPEKGFESRCSFGYEADYLVENIELIGSPFSQAVSALYPLDWEGRRAKTPAFVHDIT
PAGAAKRFLLARLGQERPAEISADLFLLGRSTPAPIGNMRIKESAEAVDERKPIGFKREEVISRDNRFLEYAYELGAAIG
GATGAGGEAPKLLLAENSAGLLYPDAVLDDEEVRQHWFVKFARNRGGQTDQDILRSEFHYYKALQTLGIETVAAEGLALE
EANKPSLWMWRFDRQVKDGAVSRFAVESIYSLAEVTTPGSAMNHLDVIRMLAGLWRKAGQASQIPGLVADYLRRDLINKI
LGNSDNHGRNTAIIRQENAFQLAPIYDLAPMVMDDEGVTRTTKWPKELERAGDVDWRGVCRVLADSADPHDSLAGLDASA
LFEGLRADARRLAALPDILAASGLPARTMNHPSVHLKNLEQRLKEWDLQ

Download         Length: 1350 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10302.09 Da        Isoelectric Point: 10.7364

>AT249198 WP_150637202.1 NZ_CP099596:c5920065-5919787 [Pseudomonas siliginis]
MSLTVLERTALIESIQQALAEGTLEIGDAVRRLRVEVTGLHQSQFAKMCKISVRTLVHIEHGEGNQTLKSLNAVFRPFGM
KMGVVRIRRDTI

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References