Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 57085..57710 Replicon plasmid unnamed
Accession NZ_CP099591
Organism Escherichia coli strain WG1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NHF37_RS23070 Protein ID WP_000911324.1
Coordinates 57085..57483 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag NHF37_RS23075 Protein ID WP_000450532.1
Coordinates 57483..57710 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF37_RS23055 (53393) 53393..53914 + 522 WP_000632670.1 conjugal transfer entry exclusion protein TraS -
NHF37_RS23060 (53939) 53939..54670 + 732 WP_000850422.1 conjugal transfer complement resistance protein TraT -
NHF37_RS23065 (54923) 54923..57076 + 2154 WP_000009350.1 type IV conjugative transfer system coupling protein TraD -
NHF37_RS23070 (57085) 57085..57483 - 399 WP_000911324.1 type II toxin-antitoxin system VapC family toxin Toxin
NHF37_RS23075 (57483) 57483..57710 - 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..67408 67408


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14800.09 Da        Isoelectric Point: 7.8604

>T249192 WP_000911324.1 NZ_CP099591:c57483-57085 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMEVIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELALQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT249192 WP_000450532.1 NZ_CP099591:c57710-57483 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References