249185

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4018950..4019764 Replicon chromosome
Accession NZ_CP099590
Organism Escherichia coli strain WG1

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag NHF37_RS19645 Protein ID WP_001054376.1
Coordinates 4018950..4019207 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag NHF37_RS19650 Protein ID WP_001309181.1
Coordinates 4019219..4019764 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF37_RS19620 (4014238) 4014238..4015344 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
NHF37_RS19625 (4015409) 4015409..4016389 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
NHF37_RS19630 (4016499) 4016499..4016704 + 206 Protein_3861 HNH endonuclease -
NHF37_RS19635 (4016972) 4016972..4018212 - 1241 Protein_3862 helicase YjhR -
NHF37_RS19640 (4018328) 4018328..4018459 + 132 WP_001309182.1 hypothetical protein -
NHF37_RS19645 (4018950) 4018950..4019207 + 258 WP_001054376.1 YjhX family toxin Toxin
NHF37_RS19650 (4019219) 4019219..4019764 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
NHF37_RS19655 (4019820) 4019820..4020566 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
NHF37_RS19660 (4020735) 4020735..4020953 + 219 Protein_3867 hypothetical protein -
NHF37_RS19665 (4020991) 4020991..4021107 + 117 Protein_3868 VOC family protein -
NHF37_RS19670 (4021352) 4021352..4022473 + 1122 WP_000010829.1 M42 family metallopeptidase -
NHF37_RS19675 (4022470) 4022470..4022748 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
NHF37_RS19680 (4022760) 4022760..4024073 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4011444..4027988 16544
- inside Genomic island - fimI / fimA / fimE / fimB 4008737..4027988 19251


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T249185 WP_001054376.1 NZ_CP099590:4018950-4019207 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT249185 WP_001309181.1 NZ_CP099590:4019219-4019764 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References