Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3442891..3443509 Replicon chromosome
Accession NZ_CP099590
Organism Escherichia coli strain WG1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NHF37_RS16855 Protein ID WP_001291435.1
Coordinates 3443291..3443509 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NHF37_RS16850 Protein ID WP_000344800.1
Coordinates 3442891..3443265 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF37_RS16840 (3437980) 3437980..3439173 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NHF37_RS16845 (3439196) 3439196..3442345 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NHF37_RS16850 (3442891) 3442891..3443265 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NHF37_RS16855 (3443291) 3443291..3443509 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NHF37_RS16860 (3443681) 3443681..3444232 + 552 WP_000102564.1 maltose O-acetyltransferase -
NHF37_RS16865 (3444348) 3444348..3444818 + 471 WP_000136192.1 YlaC family protein -
NHF37_RS16870 (3444982) 3444982..3446532 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NHF37_RS16875 (3446574) 3446574..3446927 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NHF37_RS16885 (3447306) 3447306..3447617 + 312 WP_000409911.1 MGMT family protein -
NHF37_RS16890 (3447648) 3447648..3448220 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T249179 WP_001291435.1 NZ_CP099590:3443291-3443509 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT249179 WP_000344800.1 NZ_CP099590:3442891-3443265 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References