Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 850136..850790 Replicon chromosome
Accession NZ_CP099590
Organism Escherichia coli strain WG1

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag NHF37_RS04120 Protein ID WP_000244777.1
Coordinates 850383..850790 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NHF37_RS04115 Protein ID WP_000354046.1
Coordinates 850136..850402 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF37_RS04090 (845305) 845305..846048 + 744 WP_000951964.1 SDR family oxidoreductase -
NHF37_RS04095 (846105) 846105..847538 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
NHF37_RS04100 (847583) 847583..847894 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
NHF37_RS04105 (848058) 848058..848717 + 660 WP_000250274.1 hemolysin III family protein -
NHF37_RS04110 (848913) 848913..849893 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
NHF37_RS04115 (850136) 850136..850402 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NHF37_RS04120 (850383) 850383..850790 + 408 WP_000244777.1 protein YgfX Toxin
NHF37_RS04125 (850830) 850830..851351 - 522 WP_001055874.1 flavodoxin FldB -
NHF37_RS04130 (851463) 851463..852359 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NHF37_RS04135 (852384) 852384..853094 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NHF37_RS04140 (853100) 853100..854833 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T249166 WP_000244777.1 NZ_CP099590:850383-850790 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT249166 WP_000354046.1 NZ_CP099590:850136-850402 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References