Detailed information of TA system TA024916

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-AbrB
• Location: 2316787..2317414
• Replicon: chromosome
• Accession: NC_014537
• Organism: Vulcanisaeta distributa DSM 14429

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: E1QRN0
• Locus tag: VDIS_RS12200
• Protein ID: WP_013337569.1
• Coordinates: 2317007..2317414 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: E1QRM9
• Locus tag: VDIS_RS12195
• Protein ID: WP_013337568.1
• Coordinates: 2316787..2317026 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VDIS_RS12180 (Vdis_2475)	2312342..2314204	-	1863	WP_013337565.1	urocanate hydratase	-
VDIS_RS12920	2314315..2314491	+	177	WP_171804864.1	hypothetical protein	-
VDIS_RS12185 (Vdis_2476)	2314424..2314849	+	426	WP_148678357.1	hypothetical protein	-
VDIS_RS12190 (Vdis_2477)	2315053..2316534	-	1482	WP_013337567.1	putative sulfate exporter family transporter	-
VDIS_RS12195 (Vdis_2478)	2316787..2317026	+	240	WP_013337568.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
VDIS_RS12200 (Vdis_2479)	2317007..2317414	+	408	WP_013337569.1	PIN domain-containing protein	Toxin
VDIS_RS12205 (Vdis_2480)	2317461..2318357	+	897	WP_013337570.1	arginase family protein	-
VDIS_RS12210 (Vdis_2481)	2318411..2318728	-	318	WP_013337571.1	hypothetical protein	-
VDIS_RS12215 (Vdis_2482)	2318761..2319993	-	1233	WP_052885846.1	hypothetical protein	-
VDIS_RS12220 (Vdis_2483)	2320141..2320770	-	630	WP_013337573.1	superoxide dismutase	-
VDIS_RS12225 (Vdis_2484)	2320843..2321838	+	996	WP_013337574.1	sodium:calcium antiporter	-
VDIS_RS12230 (Vdis_2485)	2321835..2322260	-	426	WP_013337575.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-126)

Antitoxin

• SpoVT-AbrB domain (5-45)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15638.20 Da
• Isoelectric Point: 6.2351

>T24916 WP_013337569.1 NC_014537:2317007-2317414 [Vulcanisaeta distributa DSM 14429]
MSEAVIDTNALIFYIVEDSREHARAVEVLNDLNRWFLPHIVIYELAWFFRSVNVPRDRATDILSNLINHRKVVLVCDNDI
IKWVLRVMRDVGWGLGGFNDLVILGTAYVLGKPLFTFDEELKRRAKRVGVEVLEV

Nucleotide

• Length: 408 bp

>T24916 NC_014537:2317007-2317414 [Vulcanisaeta distributa DSM 14429]
ATGTCAGAGGCAGTGATTGATACTAATGCGTTGATATTTTATATAGTCGAGGATTCTAGGGAGCATGCCAGGGCTGTCGA
GGTTTTAAACGACCTGAATAGGTGGTTCCTACCTCACATTGTTATTTATGAGCTGGCTTGGTTTTTTAGATCCGTTAATG
TGCCGAGGGATCGTGCTACGGACATTTTAAGTAACTTAATTAACCATAGGAAGGTGGTTTTAGTGTGTGATAATGACATT
ATTAAATGGGTATTACGTGTGATGCGGGATGTTGGCTGGGGGCTTGGCGGTTTTAATGATCTGGTAATACTTGGGACTGC
GTATGTACTTGGTAAGCCTTTATTCACGTTTGATGAGGAATTAAAGAGGAGGGCTAAGAGGGTAGGTGTTGAGGTTCTTG
AGGTTTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8952.57 Da
• Isoelectric Point: 9.9199

>AT24916 WP_013337568.1 NC_014537:2316787-2317026 [Vulcanisaeta distributa DSM 14429]
VKTLVKVTRNYQVTIPAGIRERLGIKVGDLLSVEVDGDRIILKKVIQEIPMIRLGRELTIDDINRLIEEGLMRNVRGSD

Nucleotide

• Length: 240 bp

>AT24916 NC_014537:2316787-2317026 [Vulcanisaeta distributa DSM 14429]
GTGAAGACCTTGGTTAAGGTTACTAGGAATTATCAGGTCACGATACCCGCGGGCATTAGGGAGAGGCTCGGGATTAAGGT
TGGTGATTTGTTGAGTGTTGAGGTTGATGGTGATCGTATTATCCTTAAGAAGGTTATTCAGGAGATACCAATGATCAGGT
TGGGTAGGGAGTTAACAATTGATGATATTAATAGACTCATTGAGGAGGGTTTGATGAGGAATGTCAGAGGCAGTGATTGA

Structures

Toxin

• AlphaFold DB: E1QRN0

Antitoxin

• AlphaFold DB: E1QRM9