249155

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4109086..4109681 Replicon chromosome
Accession NZ_CP099588
Organism Escherichia coli strain EMG2

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag NHF38_RS20095 Protein ID WP_000239577.1
Coordinates 4109086..4109436 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NHF38_RS20100 Protein ID WP_001223208.1
Coordinates 4109430..4109681 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF38_RS20075 (4104532) 4104532..4105554 - 1023 WP_001313531.1 ABC transporter permease -
NHF38_RS20080 (4105568) 4105568..4107070 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
NHF38_RS20085 (4107210) 4107210..4108166 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NHF38_RS20090 (4108476) 4108476..4109006 + 531 WP_000055075.1 inorganic diphosphatase -
NHF38_RS20095 (4109086) 4109086..4109436 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
NHF38_RS20100 (4109430) 4109430..4109681 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NHF38_RS20105 (4109893) 4109893..4110234 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NHF38_RS20110 (4110237) 4110237..4114016 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T249155 WP_000239577.1 NZ_CP099588:c4109436-4109086 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT249155 WP_001223208.1 NZ_CP099588:c4109681-4109430 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References