249154

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4024075..4024889 Replicon chromosome
Accession NZ_CP099588
Organism Escherichia coli strain EMG2

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag NHF38_RS19665 Protein ID WP_001054376.1
Coordinates 4024075..4024332 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag NHF38_RS19670 Protein ID WP_001309181.1
Coordinates 4024344..4024889 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF38_RS19640 (4019363) 4019363..4020469 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
NHF38_RS19645 (4020534) 4020534..4021514 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
NHF38_RS19650 (4021624) 4021624..4021829 + 206 Protein_3865 HNH endonuclease -
NHF38_RS19655 (4022097) 4022097..4023337 - 1241 Protein_3866 helicase YjhR -
NHF38_RS19660 (4023453) 4023453..4023584 + 132 WP_001309182.1 hypothetical protein -
NHF38_RS19665 (4024075) 4024075..4024332 + 258 WP_001054376.1 YjhX family toxin Toxin
NHF38_RS19670 (4024344) 4024344..4024889 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
NHF38_RS19675 (4024945) 4024945..4025691 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
NHF38_RS19680 (4025860) 4025860..4026078 + 219 Protein_3871 hypothetical protein -
NHF38_RS19685 (4026116) 4026116..4026232 + 117 Protein_3872 VOC family protein -
NHF38_RS19690 (4026477) 4026477..4027598 + 1122 WP_000010829.1 M42 family metallopeptidase -
NHF38_RS19695 (4027595) 4027595..4027873 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
NHF38_RS19700 (4027885) 4027885..4029198 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4016569..4033113 16544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T249154 WP_001054376.1 NZ_CP099588:4024075-4024332 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT249154 WP_001309181.1 NZ_CP099588:4024344-4024889 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References