Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 2001621..2001990 Replicon chromosome
Accession NC_014537
Organism Vulcanisaeta distributa DSM 14429

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag VDIS_RS12975 Protein ID WP_013337229.1
Coordinates 2001853..2001990 (+) Length 46 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID E1QPU3
Locus tag VDIS_RS10510 Protein ID WP_013337228.1
Coordinates 2001621..2001851 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VDIS_RS10485 (Vdis_2129) 1996956..1998374 - 1419 WP_013337223.1 NAD(P)/FAD-dependent oxidoreductase -
VDIS_RS10490 (Vdis_2130) 1998371..1999387 - 1017 WP_013337224.1 adenylosuccinate synthetase -
VDIS_RS10495 (Vdis_2131) 1999498..2000916 + 1419 WP_013337225.1 adenylosuccinate lyase -
VDIS_RS10500 (Vdis_2132) 2000984..2001217 + 234 WP_013337226.1 hypothetical protein -
VDIS_RS10505 (Vdis_2133) 2001214..2001462 - 249 WP_013337227.1 hypothetical protein -
VDIS_RS10510 (Vdis_2134) 2001621..2001851 + 231 WP_013337228.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
VDIS_RS12975 (Vdis_2135) 2001853..2001990 + 138 WP_013337229.1 PIN domain-containing protein Toxin
VDIS_RS10520 (Vdis_2137) 2002287..2003036 - 750 WP_013337231.1 acetoacetate decarboxylase family protein -
VDIS_RS10525 (Vdis_2138) 2003094..2004044 + 951 WP_013337232.1 (Fe-S)-binding protein -
VDIS_RS10530 (Vdis_2139) 2004044..2004358 + 315 WP_013337233.1 (Fe-S)-binding protein -
VDIS_RS10535 (Vdis_2140) 2004380..2005783 + 1404 WP_013337234.1 FAD-linked oxidase C-terminal domain-containing protein -
VDIS_RS10540 (Vdis_2141) 2005826..2006155 - 330 WP_171804860.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
VDIS_RS10545 (Vdis_2142) 2006321..2006839 + 519 WP_013337236.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-44)

Antitoxin

SpoVT-AbrB domain

(5-46)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5163.83 Da        Isoelectric Point: 3.6244

>T24915 WP_013337229.1 NC_014537:2001853-2001990 [Vulcanisaeta distributa DSM 14429]
MSFVVDTNVIIDVILEDDVNHDRAVNTWNSLNEAYVPIISLIEYL

Download         Length: 138 bp

>T24915 NC_014537:2001853-2001990 [Vulcanisaeta distributa DSM 14429]
ATGAGTTTTGTGGTTGATACAAACGTAATCATCGACGTAATTTTAGAGGATGATGTAAATCACGATAGGGCGGTGAATAC
CTGGAACTCCTTGAATGAAGCTTACGTACCAATAATCTCACTTATAGAGTACTTATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8989.66 Da        Isoelectric Point: 10.6472

>AT24915 WP_013337228.1 NC_014537:2001621-2001851 [Vulcanisaeta distributa DSM 14429]
MIEETKITRNYQITIPATIRKKLGLKVGDTLIVKLEGDRIILEPKRRSITEIRIRLGRKVDWRYVEETIREVIEKG

Download         Length: 231 bp

>AT24915 NC_014537:2001621-2001851 [Vulcanisaeta distributa DSM 14429]
ATGATTGAGGAAACGAAAATAACCAGGAATTACCAAATAACAATACCAGCAACCATTAGGAAAAAGCTTGGGTTGAAAGT
TGGGGATACACTCATAGTTAAACTTGAGGGTGACCGAATAATCCTTGAACCAAAGAGACGGAGTATCACGGAGATAAGGA
TTAGGCTGGGTAGAAAAGTTGATTGGAGATATGTTGAGGAGACCATAAGAGAGGTAATCGAGAAGGGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB E1QPU3

References