Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3436544..3437162 Replicon chromosome
Accession NZ_CP099588
Organism Escherichia coli strain EMG2

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NHF38_RS16805 Protein ID WP_001291435.1
Coordinates 3436944..3437162 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NHF38_RS16800 Protein ID WP_000344800.1
Coordinates 3436544..3436918 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF38_RS16790 (3431633) 3431633..3432826 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NHF38_RS16795 (3432849) 3432849..3435998 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NHF38_RS16800 (3436544) 3436544..3436918 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NHF38_RS16805 (3436944) 3436944..3437162 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NHF38_RS16810 (3437334) 3437334..3437885 + 552 WP_000102564.1 maltose O-acetyltransferase -
NHF38_RS16815 (3438001) 3438001..3438471 + 471 WP_000136192.1 YlaC family protein -
NHF38_RS16820 (3438635) 3438635..3440185 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NHF38_RS16825 (3440227) 3440227..3440580 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NHF38_RS16835 (3440959) 3440959..3441270 + 312 WP_000409911.1 MGMT family protein -
NHF38_RS16840 (3441301) 3441301..3441873 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T249148 WP_001291435.1 NZ_CP099588:3436944-3437162 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT249148 WP_000344800.1 NZ_CP099588:3436544-3436918 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References