Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2358995..2359633 Replicon chromosome
Accession NZ_CP099588
Organism Escherichia coli strain EMG2

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NHF38_RS11405 Protein ID WP_000813794.1
Coordinates 2359457..2359633 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NHF38_RS11400 Protein ID WP_001270286.1
Coordinates 2358995..2359411 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF38_RS11380 (2354147) 2354147..2355088 - 942 WP_001251304.1 ABC transporter permease -
NHF38_RS11385 (2355089) 2355089..2356102 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
NHF38_RS11390 (2356120) 2356120..2357265 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
NHF38_RS11395 (2357510) 2357510..2358916 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
NHF38_RS11400 (2358995) 2358995..2359411 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NHF38_RS11405 (2359457) 2359457..2359633 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NHF38_RS11410 (2359855) 2359855..2360085 + 231 WP_000494244.1 YncJ family protein -
NHF38_RS11415 (2360177) 2360177..2362138 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NHF38_RS11420 (2362211) 2362211..2362747 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
NHF38_RS11425 (2362839) 2362839..2364014 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T249147 WP_000813794.1 NZ_CP099588:c2359633-2359457 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT249147 WP_001270286.1 NZ_CP099588:c2359411-2358995 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References