Detailed information of TA system TA024913

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazE-MazF
• Location: 2034969..2035549
• Replicon: chromosome
• Accession: NC_014506
• Organism: Sulfurimonas autotrophica DSM 16294

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: E0URS6
• Locus tag: SAUT_RS10375
• Protein ID: WP_013327843.1
• Coordinates: 2034969..2035229 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: SAUT_RS10380
• Protein ID: WP_013327844.1
• Coordinates: 2035223..2035549 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAUT_RS10360	2031320..2032498	+	1179	WP_013327840.1	TolC family protein	-
SAUT_RS10365	2032513..2033493	+	981	WP_041675560.1	efflux RND transporter periplasmic adaptor subunit	-
SAUT_RS10370	2033599..2034873	-	1275	WP_013327842.1	MFS transporter	-
SAUT_RS10375	2034969..2035229	+	261	WP_013327843.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Toxin
SAUT_RS10380	2035223..2035549	+	327	WP_013327844.1	type II toxin-antitoxin system PemK/MazF family toxin	Antitoxin
SAUT_RS10385	2035656..2036657	+	1002	WP_013327845.1	virulence RhuM family protein	-
SAUT_RS10390	2037098..2037487	+	390	WP_041675562.1	hypothetical protein	-
SAUT_RS10395	2037692..2038480	+	789	WP_013327847.1	hypothetical protein	-
SAUT_RS10400	2038743..2039168	+	426	WP_013327848.1	cytochrome c	-
SAUT_RS10405	2039204..2039584	+	381	WP_013327849.1	thioredoxin family protein	-
SAUT_RS10410	2039581..2040066	+	486	WP_013327850.1	pentapeptide repeat-containing protein	-
SAUT_RS10415	2040077..2040427	+	351	WP_013327851.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• SpoVT-AbrB domain (6-46)

Antitoxin

• mRNA interferase PemK-like (6-105)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 9817.08 Da
• Isoelectric Point: 4.2690

>T24913 WP_013327843.1 NC_014506:2034969-2035229 [Sulfurimonas autotrophica DSM 16294]
MTTLTKIGNSQGIRIPKPLIQQAHLENVELELQVLENGLLIKPVNNTGREGWEKNIEEVISKHKGMQDDGVLEDLLNDSD
LEDWQW

Nucleotide

• Length: 261 bp

>T24913 NC_014506:2034969-2035229 [Sulfurimonas autotrophica DSM 16294]
ATGACAACACTCACAAAAATTGGAAACTCCCAAGGTATTAGGATTCCCAAGCCTTTAATACAACAGGCACACCTCGAAAA
TGTCGAACTTGAACTTCAAGTTTTAGAAAATGGCTTACTTATAAAGCCTGTAAACAACACAGGCAGAGAGGGATGGGAAA
AAAACATTGAAGAAGTTATATCTAAACATAAAGGTATGCAAGACGATGGAGTTTTAGAAGACTTGTTAAATGACAGTGAT
TTAGAAGACTGGCAATGGTAG

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12444.88 Da
• Isoelectric Point: 10.4426

>AT24913 WP_013327844.1 NC_014506:2035223-2035549 [Sulfurimonas autotrophica DSM 16294]
MVADIKQYEIHLVRLNPTVGSEIQKTRPCIVISPNEMNVLKTVIVVPMTSKGFDFVFRPKIKFEKKEGLVLLDQIRTVDK
TRLVKKLGDVDKKTAQEISKMLVRMFEN

Nucleotide

• Length: 327 bp

>AT24913 NC_014506:2035223-2035549 [Sulfurimonas autotrophica DSM 16294]
ATGGTAGCAGACATAAAACAATACGAAATTCACCTCGTCAGGCTCAACCCGACAGTCGGTTCTGAAATTCAAAAAACAAG
ACCCTGCATAGTCATCTCACCAAATGAAATGAATGTTTTAAAGACTGTCATAGTAGTACCCATGACGTCCAAAGGTTTTG
ATTTTGTATTTCGTCCAAAAATCAAGTTTGAAAAAAAAGAAGGACTAGTTTTACTCGACCAGATCCGAACTGTTGACAAA
ACAAGACTAGTAAAAAAACTCGGCGATGTTGACAAAAAAACAGCACAGGAAATTTCTAAAATGCTTGTAAGGATGTTTGA
AAATTGA

Structures

Toxin

• AlphaFold DB: E0URS6