Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 7108..7703 Replicon plasmid unnamed1
Accession NZ_CP099584
Organism Burkholderia glumae strain GR20004

Toxin (Protein)


Gene name chpB Uniprot ID C5AN78
Locus tag NFI99_RS12200 Protein ID WP_012734107.1
Coordinates 7353..7703 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID C5AN79
Locus tag NFI99_RS12195 Protein ID WP_012734108.1
Coordinates 7108..7359 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFI99_RS12155 (NFI99_12145) 2156..2425 + 270 WP_012732894.1 DUF1778 domain-containing protein -
NFI99_RS12160 (NFI99_12150) 2422..2910 + 489 WP_012732893.1 GNAT family N-acetyltransferase -
NFI99_RS12165 (NFI99_12155) 3317..3601 + 285 WP_017432347.1 hypothetical protein -
NFI99_RS12170 (NFI99_12160) 3615..3857 + 243 WP_124837682.1 hypothetical protein -
NFI99_RS12175 (NFI99_12165) 3854..4099 + 246 WP_127913916.1 hypothetical protein -
NFI99_RS12180 (NFI99_12170) 4156..4497 + 342 WP_012732710.1 hypothetical protein -
NFI99_RS12185 (NFI99_12175) 4500..6335 + 1836 WP_252836605.1 site-specific integrase -
NFI99_RS12190 (NFI99_12180) 6438..6845 + 408 WP_232252319.1 hypothetical protein -
NFI99_RS12195 (NFI99_12185) 7108..7359 + 252 WP_012734108.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NFI99_RS12200 (NFI99_12190) 7353..7703 + 351 WP_012734107.1 type II toxin-antitoxin system ChpB family toxin Toxin
NFI99_RS12205 (NFI99_12195) 7762..7956 + 195 WP_124837685.1 hypothetical protein -
NFI99_RS12210 (NFI99_12200) 8106..8327 + 222 WP_017433768.1 hypothetical protein -
NFI99_RS12215 (NFI99_12205) 8550..9014 + 465 WP_012734106.1 Lrp/AsnC family transcriptional regulator -
NFI99_RS12220 (NFI99_12210) 9328..11703 + 2376 WP_232252305.1 TonB-dependent receptor -
NFI99_RS12225 (NFI99_12215) 11735..12481 + 747 WP_232252306.1 energy transducer TonB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..154173 154173


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12389.37 Da        Isoelectric Point: 8.8909

>T249128 WP_012734107.1 NZ_CP099584:7353-7703 [Burkholderia glumae]
MVKRVKFERGDIVRVSLSPTVGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGSGTETQGVALV
NMVRMLDLEGRGARKIERAPVEVVEDALARLQTIIE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8940.31 Da        Isoelectric Point: 6.2420

>AT249128 WP_012734108.1 NZ_CP099584:7108-7359 [Burkholderia glumae]
MELKIQKWGNSAAVRLPSVLLEQINASVGGSLNADVRPDGVLLTPARRKYALDDLVAQCDTKAPVPADMAAWGEIKPVGR
EAW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246MF70

Antitoxin

Source ID Structure
AlphaFold DB A0A246MFN5

References