Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1701875..1702650 Replicon chromosome
Accession NZ_CP099583
Organism Burkholderia glumae strain GR20004

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag NFI99_RS06865 Protein ID WP_015877380.1
Coordinates 1701875..1702372 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag NFI99_RS06870 Protein ID WP_015877381.1
Coordinates 1702369..1702650 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFI99_RS06830 (NFI99_06825) 1697329..1698678 + 1350 WP_015877376.1 allantoin permease -
NFI99_RS06835 (NFI99_06830) 1698764..1698859 - 96 Protein_1359 IS5/IS1182 family transposase -
NFI99_RS06840 (NFI99_06835) 1698931..1699476 - 546 Protein_1360 IS3 family transposase -
NFI99_RS06845 (NFI99_06840) 1699599..1699883 - 285 WP_153478924.1 hypothetical protein -
NFI99_RS06850 (NFI99_06845) 1699900..1700151 - 252 WP_230674552.1 hypothetical protein -
NFI99_RS06855 (NFI99_06850) 1700281..1700883 - 603 Protein_1363 RHS domain-containing protein -
NFI99_RS06860 (NFI99_06855) 1701297..1701794 - 498 WP_015877379.1 ProQ/FINO family protein -
NFI99_RS06865 (NFI99_06860) 1701875..1702372 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
NFI99_RS06870 (NFI99_06865) 1702369..1702650 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
NFI99_RS06875 (NFI99_06870) 1702647..1703024 - 378 WP_173941242.1 hypothetical protein -
NFI99_RS06880 (NFI99_06875) 1703107..1703469 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1691256..1717406 26150
- flank IS/Tn - - 1698907..1699449 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T249127 WP_015877380.1 NZ_CP099583:c1702372-1701875 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT249127 WP_015877381.1 NZ_CP099583:c1702650-1702369 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References