249122

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2213233..2213747 Replicon chromosome
Accession NZ_CP099576
Organism Staphylococcus aureus strain MRSA1369

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NHB12_RS11085 Protein ID WP_000581792.1
Coordinates 2213233..2213442 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NHB12_RS11090 Protein ID WP_000138932.1
Coordinates 2213454..2213747 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHB12_RS11065 (2208741) 2208741..2210099 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NHB12_RS11070 (2210114) 2210114..2211184 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NHB12_RS11075 (2211502) 2211502..2212704 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NHB12_RS11080 (2212968) 2212968..2213105 - 138 WP_000828354.1 Lmo0850 family protein -
NHB12_RS11085 (2213233) 2213233..2213442 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NHB12_RS11090 (2213454) 2213454..2213747 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NHB12_RS11095 (2213913) 2213913..2215397 + 1485 WP_000571549.1 cardiolipin synthase -
NHB12_RS11100 (2215425) 2215425..2216072 + 648 WP_001187629.1 HD domain-containing protein -
NHB12_RS11105 (2216885) 2216885..2217757 - 873 WP_000725802.1 membrane protein insertase YidC -
NHB12_RS11110 (2217843) 2217843..2218484 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T249122 WP_000581792.1 NZ_CP099576:c2213442-2213233 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT249122 WP_000138932.1 NZ_CP099576:c2213747-2213454 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References