Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2193477..2194006 Replicon chromosome
Accession NZ_CP099576
Organism Staphylococcus aureus strain MRSA1369

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NHB12_RS10995 Protein ID WP_000621175.1
Coordinates 2193477..2193839 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NHB12_RS11000 Protein ID WP_000948331.1
Coordinates 2193836..2194006 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHB12_RS10975 (2190455) 2190455..2191225 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
NHB12_RS10980 (2191200) 2191200..2191679 - 480 WP_001190829.1 anti-sigma B factor RsbW -
NHB12_RS10985 (2191681) 2191681..2192007 - 327 WP_001052491.1 anti-sigma factor antagonist -
NHB12_RS10990 (2192126) 2192126..2193127 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NHB12_RS10995 (2193477) 2193477..2193839 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NHB12_RS11000 (2193836) 2193836..2194006 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NHB12_RS11005 (2194091) 2194091..2195239 - 1149 WP_001281145.1 alanine racemase -
NHB12_RS11010 (2195305) 2195305..2195664 - 360 WP_000581200.1 holo-ACP synthase -
NHB12_RS11015 (2195668) 2195668..2196159 - 492 WP_001205910.1 PH domain-containing protein -
NHB12_RS11020 (2196146) 2196146..2197729 - 1584 WP_001294626.1 PH domain-containing protein -
NHB12_RS11025 (2197722) 2197722..2198201 - 480 WP_001287088.1 hypothetical protein -
NHB12_RS11030 (2198409) 2198409..2198969 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T249121 WP_000621175.1 NZ_CP099576:c2193839-2193477 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT249121 WP_000948331.1 NZ_CP099576:c2194006-2193836 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References