Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1992781..1993557 Replicon chromosome
Accession NZ_CP099576
Organism Staphylococcus aureus strain MRSA1369

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NHB12_RS09730 Protein ID WP_000031108.1
Coordinates 1992781..1992933 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NHB12_RS09735 Protein ID WP_001251224.1
Coordinates 1992958..1993557 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHB12_RS09715 (1988744) 1988744..1989565 + 822 WP_000669376.1 RluA family pseudouridine synthase -
NHB12_RS09720 (1990028) 1990028..1991413 - 1386 WP_000116224.1 class II fumarate hydratase -
NHB12_RS09725 (1991609) 1991609..1992004 - 396 WP_000901021.1 hypothetical protein -
NHB12_RS09730 (1992781) 1992781..1992933 - 153 WP_000031108.1 SAS053 family protein Toxin
NHB12_RS09735 (1992958) 1992958..1993557 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NHB12_RS09740 (1993716) 1993716..1994186 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NHB12_RS09745 (1994191) 1994191..1995318 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
NHB12_RS09750 (1995469) 1995469..1996191 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NHB12_RS09755 (1996184) 1996184..1997641 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T249117 WP_000031108.1 NZ_CP099576:c1992933-1992781 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT249117 WP_001251224.1 NZ_CP099576:c1993557-1992958 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References