Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5956396..5957027 Replicon chromosome
Accession NZ_CP099575
Organism Pseudomonas kermanshahensis strain F8

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NG836_RS26860 Protein ID WP_099430453.1
Coordinates 5956800..5957027 (-) Length 76 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NG836_RS26855 Protein ID WP_099430452.1
Coordinates 5956396..5956803 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NG836_RS26835 (NG836_26835) 5953043..5954365 + 1323 WP_252825873.1 phosphatase PAP2/dual specificity phosphatase family protein -
NG836_RS26840 (NG836_26840) 5954362..5954793 + 432 WP_252825874.1 hypothetical protein -
NG836_RS26845 (NG836_26845) 5954804..5955427 + 624 WP_027595452.1 lysophospholipid acyltransferase family protein -
NG836_RS26850 (NG836_26850) 5955429..5956361 + 933 WP_027595453.1 phosphatidate cytidylyltransferase -
NG836_RS26855 (NG836_26855) 5956396..5956803 - 408 WP_099430452.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NG836_RS26860 (NG836_26860) 5956800..5957027 - 228 WP_099430453.1 type II toxin-antitoxin system HicA family toxin Toxin
NG836_RS26865 (NG836_26865) 5957303..5957647 + 345 WP_003251579.1 cupin domain-containing protein -
NG836_RS26870 (NG836_26870) 5957880..5958767 - 888 WP_027595454.1 3-hydroxyisobutyrate dehydrogenase -
NG836_RS26875 (NG836_26875) 5958778..5960304 - 1527 WP_085273919.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
NG836_RS26880 (NG836_26880) 5960437..5961387 + 951 WP_099430457.1 LysR family transcriptional regulator -
NG836_RS26885 (NG836_26885) 5961529..5962017 - 489 WP_099455320.1 OmpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8315.30 Da        Isoelectric Point: 10.5627

>T249114 WP_099430453.1 NZ_CP099575:c5957027-5956800 [Pseudomonas kermanshahensis]
MRSREVIQLIEADGWYEVEVKGSHHQFRHPTKRGRVTVPHPKSDLPKGTVHSILKQAGLKQPNGSNSSSTSGDTQ

Download         Length: 228 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14672.49 Da        Isoelectric Point: 4.7169

>AT249114 WP_099430452.1 NZ_CP099575:c5956803-5956396 [Pseudomonas kermanshahensis]
MKFPVVLHKDADSDYGVTVPDVPGCFSAGASVSQALENVQEALALHFEGLVADNEALPQAQEIDVHVANPDYQGGVWAVV
DFDVTPYLGKAVRFNATLPENLLQRIDEKVKRDHRYASRSGFLASAALRELAIAH

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References