Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2021169..2021737 Replicon chromosome
Accession NZ_CP099556
Organism Aliarcobacter cryaerophilus strain ICDCAC48

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NGX11_RS10590 Protein ID WP_260947991.1
Coordinates 2021169..2021501 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NGX11_RS10595 Protein ID WP_263514512.1
Coordinates 2021495..2021737 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGX11_RS10570 (NGX11_10520) 2016627..2017190 + 564 WP_066165328.1 YceI family protein -
NGX11_RS10575 (NGX11_10525) 2017231..2018436 - 1206 WP_263514510.1 tryptophan synthase subunit beta -
NGX11_RS10580 (NGX11_10530) 2018500..2019792 + 1293 WP_187472906.1 saccharopine dehydrogenase C-terminal domain-containing protein -
NGX11_RS10585 (NGX11_10535) 2019863..2021179 + 1317 WP_263514511.1 aminotransferase class V-fold PLP-dependent enzyme -
NGX11_RS10590 (NGX11_10540) 2021169..2021501 - 333 WP_260947991.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NGX11_RS10595 (NGX11_10545) 2021495..2021737 - 243 WP_263514512.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NGX11_RS10600 (NGX11_10550) 2021891..2022484 - 594 WP_260875402.1 porin family protein -
NGX11_RS10605 (NGX11_10555) 2022577..2022867 + 291 WP_236778534.1 helix-turn-helix transcriptional regulator -
NGX11_RS10610 (NGX11_10560) 2022913..2024064 + 1152 WP_263514513.1 metallophosphoesterase -
NGX11_RS10615 (NGX11_10565) 2024076..2024492 - 417 WP_066156012.1 Hsp20/alpha crystallin family protein -
NGX11_RS10620 (NGX11_10570) 2024595..2025038 - 444 WP_066404045.1 hemerythrin family protein -
NGX11_RS10625 (NGX11_10575) 2025105..2026151 - 1047 WP_263514514.1 sulfate ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-107)

Antitoxin

Antitoxin PemI-like

(1-80)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12493.56 Da        Isoelectric Point: 9.5322

>T249110 WP_260947991.1 NZ_CP099556:c2021501-2021169 [Aliarcobacter cryaerophilus]
MVNYIPSKGDIVTLDFDPQKGHEQKGRRPALILSNKTFNKALGLAFACPITSTKRDFPFHIKIQSQKISGFIMAEQLKSI
DYNSRNIKFVEKVDKEILEEIEAIVDAIIK

Download         Length: 333 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9039.40 Da        Isoelectric Point: 9.5169

>AT249110 WP_263514512.1 NZ_CP099556:c2021737-2021495 [Aliarcobacter cryaerophilus]
MIVTISKWGNSQGFRIPKDILDKLNLTVGDLVNISQKDNKLIIEPAKKEKKYSIDELVNNLPKGYKASEEFSSKSGSEIW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References