249108

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 1885932..1886497 Replicon chromosome
Accession NZ_CP099551
Organism Lactiplantibacillus pentosus strain KW1

Toxin (Protein)


Gene name mazF Uniprot ID F6IUY4
Locus tag NGP02_RS08335 Protein ID WP_050339912.1
Coordinates 1886150..1886497 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NGP02_RS08330 Protein ID WP_082230320.1
Coordinates 1885932..1886150 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGP02_RS08315 1881547..1883589 + 2043 WP_252701470.1 KUP/HAK/KT family potassium transporter -
NGP02_RS08320 1883657..1884304 - 648 WP_225351393.1 N-acetyltransferase -
NGP02_RS08325 1884443..1885174 - 732 WP_050339911.1 hypothetical protein -
NGP02_RS08330 1885932..1886150 + 219 WP_082230320.1 hypothetical protein Antitoxin
NGP02_RS08335 1886150..1886497 + 348 WP_050339912.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NGP02_RS08340 1886917..1887960 - 1044 WP_021337327.1 AI-2E family transporter -
NGP02_RS08345 1888413..1889537 + 1125 WP_050339913.1 vitamin B12 independent methionine synthase -
NGP02_RS08350 1889692..1890072 - 381 WP_225351394.1 multidrug efflux SMR transporter -
NGP02_RS08355 1890092..1890400 - 309 WP_003639898.1 SMR family transporter -
NGP02_RS08360 1890776..1891414 - 639 WP_050339915.1 hemolysin III family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-93)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13406.29 Da        Isoelectric Point: 9.4892

>T249108 WP_050339912.1 NZ_CP099551:1886150-1886497 [Lactiplantibacillus pentosus]
MTYLPKQKDIIWIDFDPQRGREIKKRRPAVILSSNLYTQNTGFVIVSPITSTIHDLPGYFSLNGYDIHGQVVAAQIYSFD
ARPKAGRNITYIETMRNVDFYRVAQTVYYNFDFPF

Download         Length: 348 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8175.33 Da        Isoelectric Point: 9.6576

>AT249108 WP_082230320.1 NZ_CP099551:1885932-1886150 [Lactiplantibacillus pentosus]
MIEVKTVSRGNSLALSLPKDGRFKKGQRWLLIPSKDGESYTLVPRIENPYAGPKSKQPMTEAWSDVNWNEVE

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F6IUY4

Antitoxin

Source ID Structure

References